{"id":"W2954387225","doi":"10.3389/fvets.2019.00233","title":"Synthetic Cationic Peptide IDR-1002 and Human Cathelicidin LL37 Modulate the Cell Innate Response but Differentially Impact PRRSV Replication in vitro","year":2019,"lang":"en","type":"article","venue":"Frontiers in Veterinary Science","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"European Regional Development Fund; Conseil Régional des Pays de la Loire; Mitacs; Alberta Livestock and Meat Agency; Canadian Swine Health Board","keywords":"Innate immune system; Cathelicidin; Adjuvant; Immune system; Biology; In vitro; Antimicrobial peptides; Porcine reproductive and respiratory syndrome virus; Beta defensin; Immunology; Peptide; Cell biology; Virus; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001866818,0.0003059014,0.0002458202,0.00009508874,0.00007280718,0.0002490171,0.0001306195,0.0002910403,0.0006816192],"category_scores_gemma":[0.0001596701,0.0001048675,0.0001738446,0.00009673775,0.0001582487,0.0001569931,0.0001479693,0.0004234191,0.0003089537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001299498,"about_ca_system_score_gemma":0.0001164378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002349514,"about_ca_topic_score_gemma":0.0002626544,"domain_scores_codex":[0.9997312,0.0000849382,0.00002691915,0.00004184433,0.00005466238,0.00006034922],"domain_scores_gemma":[0.9998803,0.0000483339,0.00002192356,0.00001326418,0.00001332848,0.00002274703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000140122,0.00004281088,0.00009426154,0.00002387402,0.000002448148,0.00002039379,0.00001184772,0.0000652144,0.9991741,0.00001540871,0.00001082639,0.0003987231],"study_design_scores_gemma":[0.00002277293,0.001667932,0.002304392,0.000005646756,0.00001178007,0.0001178109,0.00003442642,0.0007701907,0.9942445,0.00002223197,0.0007947202,0.000003654463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973714,0.0009960704,0.0007944479,0.00003044434,0.00001707182,0.00001925806,0.0001114087,0.00001026611,0.0006495266],"genre_scores_gemma":[0.9968977,0.0004569909,0.001345568,0.00004685541,0.0000107393,0.00003460801,0.0003111099,0.000004790587,0.0008918006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006816192,"threshold_uncertainty_score":0.002280235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01077620705051899,"score_gpt":0.2492061487845617,"score_spread":0.2384299417340427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}