{"id":"W2954398156","doi":"10.2196/14636","title":"Safety and Efficacy of Bis-Glyceryl Ascorbate (Amitose DGA) to Prevent Hand-Foot Skin Reaction in Patients With Renal Cell Carcinoma Receiving Sunitinib Therapy: Protocol for a Phase I/II, Uncontrolled, Single-Arm, Open-Label Trial","year":2019,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Vitamin C and Antioxidants Research","field":"Nursing","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Sunitinib; Medicine; Renal cell carcinoma; Ascorbic acid; Adverse effect; Dosing; Clinical trial; Internal medicine; Surgery; Oncology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005586192,0.002695612,0.00418894,0.0007043167,0.001303221,0.001354764,0.001792697,0.002884615,0.01154677],"category_scores_gemma":[0.003416386,0.001026109,0.00233507,0.0007069932,0.001557393,0.001548134,0.0006288808,0.003703528,0.002212059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00155479,"about_ca_system_score_gemma":0.005650993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009236909,"about_ca_topic_score_gemma":0.002076519,"domain_scores_codex":[0.9981482,0.0009122824,0.0001624714,0.000270466,0.0002030677,0.0003034995],"domain_scores_gemma":[0.9976858,0.0002849089,0.0004964503,0.0002430818,0.0003183005,0.0009714781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9235671,0.04691451,0.001303253,0.001442195,0.0006550991,0.00009183997,0.0001193496,0.0008076771,0.008861343,0.0001429172,0.001782202,0.01431263],"study_design_scores_gemma":[0.8323116,0.1613977,0.002403537,0.00005973678,0.0003020238,0.00004194839,0.00002717841,0.0003482461,0.0009726689,0.0001322991,0.001978027,0.00002509663],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.498034,0.002511993,0.003154078,0.001054807,0.0005803793,0.48495,0.005318249,0.000328478,0.004067948],"genre_scores_gemma":[0.5017971,0.001980632,0.008515089,0.002141292,0.0004421032,0.4771273,0.0035158,0.00004872794,0.004431985],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.01154677,"threshold_uncertainty_score":0.03862774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1418336330779658,"score_gpt":0.4782689500392946,"score_spread":0.3364353169613289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}