{"id":"W2954422833","doi":"10.3389/fneur.2019.00716","title":"Dosage Related Efficacy and Tolerability of Cannabidiol in Children With Treatment-Resistant Epileptic Encephalopathy: Preliminary Results of the CARE-E Study","year":2019,"lang":"en","type":"article","venue":"Frontiers in Neurology","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; University of Manitoba; BC Children's Hospital; University of British Columbia; Saskatchewan Health Authority; Royal University Hospital; Université de Montréal; University of Saskatchewan","funders":"Saskatchewan Health Research Foundation; Savoy Foundation","keywords":"Cannabidiol; Tolerability; Medicine; Epilepsy; Cannabis; Anesthesia; Anticonvulsant; Pharmacokinetics; Adverse effect; Cannabinoid; Placebo; Pharmacology; Internal medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001714743,0.0006620759,0.001067229,0.000273416,0.0003223265,0.0003483045,0.0004754791,0.0006803948,0.0008192955],"category_scores_gemma":[0.003682435,0.000228525,0.0008141083,0.0003653394,0.0006844401,0.0004248694,0.0003281842,0.001181797,0.0001819343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006982114,"about_ca_system_score_gemma":0.000771685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001294811,"about_ca_topic_score_gemma":0.002043151,"domain_scores_codex":[0.9985026,0.0007071653,0.0001789913,0.0001290729,0.0003683906,0.0001136961],"domain_scores_gemma":[0.9973361,0.0009306576,0.0007604358,0.0002949676,0.0002813666,0.000396429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3067766,0.06805133,0.2663041,0.001597186,0.002102105,0.004461424,0.00225271,0.002706376,0.1353662,0.0002151548,0.001511787,0.2086549],"study_design_scores_gemma":[0.0293496,0.5896183,0.3514308,0.00005131894,0.0007813768,0.002905706,0.0003571086,0.0008688878,0.0221181,0.00007421845,0.002394136,0.00005043142],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991102,0.0003295386,0.0001032496,0.00002738415,0.0000035173,0.0001196636,0.0000795086,0.000008477375,0.0002184822],"genre_scores_gemma":[0.9983414,0.0003126314,0.0006113005,0.00007938472,0.00002050628,0.0001687865,0.0003052032,0.000006612451,0.0001541213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001714743,"threshold_uncertainty_score":0.009068489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00474761727776705,"score_gpt":0.2352126338666102,"score_spread":0.2304650165888432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}