{"id":"W2954425512","doi":"10.1038/s41467-019-10828-3","title":"An anionic human protein mediates cationic liposome delivery of genome editing proteins into mammalian cells","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of General Medical Sciences; National Human Genome Research Institute; Defense Advanced Research Projects Agency; U.S. Department of Health and Human Services; National Institutes of Health; Howard Hughes Medical Institute; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Bill and Melinda Gates Foundation; NIH Office of the Director; U.S. Department of Defense","keywords":"Genome editing; Cationic polymerization; Liposome; Cationic liposome; Genome; Computational biology; Cell biology; Chemistry; Biology; Transfection; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004151652,0.0002973166,0.0001711782,0.0001418323,0.0001556681,0.0004032666,0.000211789,0.0002997323,0.0008161429],"category_scores_gemma":[0.0001836782,0.00010831,0.0001679798,0.0001272229,0.0002674415,0.0002354571,0.0003166711,0.0002718354,0.0005375643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003248432,"about_ca_system_score_gemma":0.0002169189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000443154,"about_ca_topic_score_gemma":0.0004694352,"domain_scores_codex":[0.9997955,0.00004542698,0.00002113487,0.00004618914,0.00005849885,0.00003328764],"domain_scores_gemma":[0.9998889,0.00002739402,0.00003119484,0.00001235837,0.00001679297,0.00002328391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002259415,0.000004296955,0.00003001127,0.00001429701,0.000001340512,0.00002648508,0.000009932361,0.00002470685,0.9993443,0.00009909659,0.00001126715,0.0004116959],"study_design_scores_gemma":[0.000005388802,0.00004686172,0.0002489212,0.000002147405,0.000002696773,0.0001207978,0.000007013438,0.0002738081,0.9979213,0.00001883287,0.001350637,0.000001632186],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9730574,0.001126085,0.02120608,0.0001265829,0.00003336652,0.0001550271,0.0003129866,0.0001689555,0.003813488],"genre_scores_gemma":[0.9895266,0.0005586398,0.006367953,0.00005437548,0.000005680554,0.00003338195,0.0003288982,0.00003518011,0.003089228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008161429,"threshold_uncertainty_score":0.00273025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00913465662998007,"score_gpt":0.2680945525199668,"score_spread":0.2589598958899867,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}