{"id":"W2954453953","doi":"10.1016/s2213-8587(19)30158-5","title":"Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial","year":2019,"lang":"en","type":"article","venue":"The Lancet Diabetes & Endocrinology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":328,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian VIGOUR Centre; University of Toronto; University of Alberta; St. Michael's Hospital","funders":"Gilead UK and Ireland Corporate Contributions; Seventh Framework Programme; Daiichi Sankyo Europe; St. Jude Medical; Esperion Therapeutics; Idorsia Pharmaceuticals; Biotronik; Ferring Pharmaceuticals; NIHR Imperial Biomedical Research Centre; Eisai; Daiichi-Sankyo; Hartstichting; Actavis; Bayer HealthCare; Ironwood Pharmaceuticals, Incorporated; Medicines Company; Arrien Pharmaceuticals; Tenax Therapeutics; Janssen Pharmaceuticals; Novo Nordisk; MyoKardia; Assistance publique-Hôpitaux de Paris; Luitpold Pharmaceuticals; Regado Biosciences; Merck Sharp and Dohme; Novartis; Belvoir Media Group; Portola Pharmaceuticals; Boston Scientific Corporation; Bristol-Myers Squibb; Cleveland Clinic; Boehringer Ingelheim; American College of Cardiology Foundation; Sanofi; National Lipid Association; GlaxoSmithKline; Mayo Clinic; Merck; Servier; Abbott Laboratories; Bayer; National Institute for Health and Care Research; CSL Behring; Pfizer; Icahn School of Medicine at Mount Sinai; Eli Lilly and Company; Amarin Corporation; Genentech; AstraZeneca; Roche; Flatiron Health; Duke Clinical Research Institute; Astellas Pharma US; Amgen; Regeneron Pharmaceuticals; American Heart Association","keywords":"Medicine; Alirocumab; Acute coronary syndrome; Diabetes mellitus; Internal medicine; Metabolic syndrome; Randomized controlled trial; MEDLINE; Cardiology; Myocardial infarction; Cholesterol; Endocrinology; Total cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008391159,0.0003729873,0.005640545,0.0003124796,0.00004144771,0.00000958146,0.0003105108,0.0001102525,0.00002847632],"category_scores_gemma":[0.0002654572,0.0001549034,0.001354241,0.0005227339,0.0002316101,0.00005382108,0.0001329337,0.0003214982,0.000002227599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003595696,"about_ca_system_score_gemma":0.00007302244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006471259,"about_ca_topic_score_gemma":0.00002375493,"domain_scores_codex":[0.9963573,0.0009822876,0.0006649701,0.0004527463,0.0007215094,0.000821145],"domain_scores_gemma":[0.9968966,0.001019044,0.0003223478,0.001585733,0.0001021102,0.00007417314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1426944,0.0002694321,0.8144883,0.000200384,0.04137455,0.00001737138,0.0001194159,0.00003270843,0.00003689034,0.00002895999,0.000002235209,0.0007353508],"study_design_scores_gemma":[0.3798911,0.0008624042,0.6075863,0.00006867736,0.01109727,0.000001626579,0.000009875292,0.00002544483,0.0003061689,0.000007753603,0.00003491371,0.0001084519],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876454,0.002463543,0.000001595874,0.0002616741,0.0002150631,0.009310899,0.00003523655,0.00002498063,0.00004156894],"genre_scores_gemma":[0.9977179,0.000231336,0.00002983894,0.0006325618,0.00003463035,0.001211698,0.00001100393,0.00003553545,0.00009553391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2371967,"threshold_uncertainty_score":0.6316778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00810748051552855,"score_gpt":0.2400447541565947,"score_spread":0.2319372736410662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}