{"id":"W2954455527","doi":"10.1128/aac.00472-19","title":"Thiostrepton Hijacks Pyoverdine Receptors To Inhibit Growth of Pseudomonas aeruginosa","year":2019,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Glycomics Network; Cystic Fibrosis Canada; Natural Sciences and Engineering Research Council of Canada; Government of Canada; Ontario Research Foundation","keywords":"Thiostrepton; Pseudomonas aeruginosa; Pyoverdine; Microbiology; Biofilm; Antibiotics; Biology; Bacteria; Pathogen; Opportunistic pathogen; Gene; RNA; Biochemistry; Ribosome; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007056171,0.0002990795,0.0001267828,0.0001124074,0.00007945473,0.0001974315,0.0001777456,0.0001973152,0.000844516],"category_scores_gemma":[0.0001113597,0.00008962317,0.0001309223,0.0000868289,0.0001794162,0.0001268275,0.0001909905,0.0003660423,0.0001989734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002038258,"about_ca_system_score_gemma":0.0001635899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009213054,"about_ca_topic_score_gemma":0.001125546,"domain_scores_codex":[0.9998916,0.00001774043,0.000008225946,0.00001454045,0.00004223894,0.00002562119],"domain_scores_gemma":[0.9999214,0.00001954079,0.00001953084,0.00001137984,0.000008040061,0.00002005614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003008854,0.00001043005,0.00008053892,0.00000451163,0.000001441907,0.00002191779,0.00000425336,0.00002782605,0.999352,0.00005200633,0.000009555577,0.0004053911],"study_design_scores_gemma":[0.000004109345,0.0001878495,0.001859734,0.000001778999,0.000005214468,0.000129867,0.00001673388,0.0009810084,0.9962977,0.00002575685,0.0004879465,0.000002333841],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980008,0.0002321224,0.0008663312,0.00005854881,0.000008621228,0.000005087611,0.00004413094,0.00002298128,0.0007614291],"genre_scores_gemma":[0.9982858,0.0001236007,0.0003167013,0.00001684821,0.000002397832,0.000003750802,0.00006186743,0.000007576381,0.001181436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009213054,"threshold_uncertainty_score":0.002825141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005171223814129705,"score_gpt":0.2160411996416217,"score_spread":0.210869975827492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}