{"id":"W2954482364","doi":"10.1158/1538-7445.sabcs18-1023","title":"Abstract 1023: Combining all-trans retinoic acid therapy with androgen receptor N-terminal domain inhibitors for the treatment of castration-resistant prostate cancer","year":2019,"lang":"en","type":"article","venue":"","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Androgen receptor; Transactivation; Prostate cancer; LNCaP; Bicalutamide; Cancer research; Androgen deprivation therapy; Biology; Dihydrotestosterone; Signal transduction; Endocrinology; Chemistry; Androgen; Internal medicine; Cancer; Cell biology; Medicine; Transcription factor; Biochemistry; Gene; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001358682,0.0003545496,0.0003887387,0.0002325116,0.0001438987,0.0002589663,0.0003076366,0.0002567255,0.002779003],"category_scores_gemma":[0.00004876636,0.00009259253,0.0002833745,0.0001616587,0.0001440272,0.0001600955,0.0001248583,0.0006267142,0.0006066557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002249886,"about_ca_system_score_gemma":0.0004067627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007070487,"about_ca_topic_score_gemma":0.002466145,"domain_scores_codex":[0.9999394,0.0000130161,0.000004433267,0.00000750617,0.00001698852,0.00001854032],"domain_scores_gemma":[0.9999762,0.000002456306,0.000004846572,0.000002375102,0.000002666101,0.00001145854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005443536,0.003015922,0.0007494827,0.0004500341,0.0001271145,0.0003288209,0.00005411228,0.0009739733,0.8941489,0.0007882452,0.001636698,0.09228322],"study_design_scores_gemma":[0.004512194,0.0613709,0.01483261,0.00008031092,0.0003366011,0.002535965,0.0000912243,0.003445576,0.8724374,0.0003290321,0.03998268,0.00004567729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9685177,0.01383898,0.002870568,0.0004458145,0.0002046332,0.0005998755,0.000794734,0.0002476562,0.0124801],"genre_scores_gemma":[0.9852314,0.004200581,0.002841337,0.0002190035,0.00003112221,0.0001316274,0.0006486627,0.00002090991,0.006675318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002779003,"threshold_uncertainty_score":0.009296715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01652830879227166,"score_gpt":0.2724339506172784,"score_spread":0.2559056418250067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}