{"id":"W2954536666","doi":"10.1016/j.omtm.2019.05.013","title":"Generation of High-Titer Self-Inactivated γ-Retroviral Vector Producer Cells","year":2019,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children; Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Titer; Virology; Viral vector; Vector (molecular biology); Biology; Virus; Genetics; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003245266,0.0003565737,0.0005458065,0.0001104935,0.00006725373,0.00003463464,0.0004798205,0.000380376,0.0002558559],"category_scores_gemma":[0.0001427265,0.0003141025,0.0002672908,0.0002741207,0.00009393982,0.000009131031,0.0001733014,0.0003109059,0.00009978314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006604062,"about_ca_system_score_gemma":0.0005191903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009831966,"about_ca_topic_score_gemma":0.000005007019,"domain_scores_codex":[0.9952968,0.001824747,0.0009578823,0.000961253,0.0004746955,0.0004846615],"domain_scores_gemma":[0.9981411,0.00009030141,0.0002840327,0.0009877569,0.0003245503,0.0001722843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001550952,0.0004191119,0.0009269669,0.00002045073,0.0005074983,0.000003694303,0.00008283319,0.00006641713,0.9130599,0.00002092542,0.0001704123,0.08317085],"study_design_scores_gemma":[0.001989451,0.002967815,0.003020677,0.00001265861,0.00001407268,0.000001650371,0.00000775167,0.00008588893,0.9649871,0.00004570438,0.02648668,0.0003805398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781767,0.0007315318,0.01911175,0.0001817428,0.0006872755,0.0009502441,0.000005806691,0.00003670312,0.0001182646],"genre_scores_gemma":[0.7486649,0.0004310613,0.2486344,0.0009254121,0.0002426961,0.00008341189,0.0001449631,0.00009128574,0.0007819137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2295226,"threshold_uncertainty_score":0.9999311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07364101910277951,"score_gpt":0.4162188386070853,"score_spread":0.3425778195043058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}