{"id":"W2954536666","doi":"10.1016/j.omtm.2019.05.013","title":"Generation of High-Titer Self-Inactivated γ-Retroviral Vector Producer Cells","year":2019,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children; Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Titer; Virology; Viral vector; Vector (molecular biology); Biology; Virus; Genetics; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001613982,0.0007463856,0.0009663371,0.0006718712,0.0003953128,0.001170375,0.0009464979,0.0008830291,0.003939624],"category_scores_gemma":[0.0006754816,0.0005383557,0.0005768063,0.0005059798,0.0003688856,0.0004809558,0.0007110464,0.0024664,0.004697317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003711122,"about_ca_system_score_gemma":0.0003524525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002732748,"about_ca_topic_score_gemma":0.0002689335,"domain_scores_codex":[0.9988691,0.000178458,0.0001730908,0.0002267868,0.0004292488,0.0001231908],"domain_scores_gemma":[0.999449,0.0001114404,0.00007423604,0.0001493749,0.0001506771,0.00006533438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008279903,0.000110133,0.0002144295,0.0001038833,0.00001192956,0.0001345216,0.0001323698,0.0001652567,0.9928781,0.001108483,0.00059337,0.00446466],"study_design_scores_gemma":[0.0000602578,0.0004414498,0.000896926,0.00003875321,0.00005857561,0.0005269835,0.00005220367,0.00280078,0.9634215,0.0002768813,0.03140264,0.00002302654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5073025,0.005774027,0.4405591,0.0005522716,0.001051681,0.004830991,0.009791059,0.002852495,0.02728584],"genre_scores_gemma":[0.7026173,0.004825986,0.2158309,0.0005481486,0.0002246292,0.003601498,0.02536715,0.001118113,0.04586635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003939624,"threshold_uncertainty_score":0.01317936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07364101910277951,"score_gpt":0.4162188386070853,"score_spread":0.3425778195043058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}