{"id":"W2954572909","doi":"10.1124/jpet.118.256016","title":"Experimental Autoimmune Encephalomyelitis Potentiates Mouse Mast Cell Protease 4–Dependent Pressor Responses to Centrally or Systemically Administered Big Endothelin-1","year":2019,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Multiple Sclerosis Society; Fonds de Recherche du Québec - Santé; Multiple Sclerosis Society of Canada; Université de Montréal; Université de Sherbrooke","keywords":"Medicine; Experimental autoimmune encephalomyelitis; Immunology; Mast cell; Endothelin receptor; Tumor necrosis factor alpha; Encephalomyelitis; Knockout mouse; Pharmacology; Endocrinology; Internal medicine; Immune system; Multiple sclerosis; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003262403,0.0003592718,0.0006160298,0.0001961091,0.0001894181,0.00004933104,0.0004064948,0.0002469074,0.003181748],"category_scores_gemma":[0.000006435033,0.0002768724,0.000163196,0.00007590894,0.0002065742,0.0001391903,0.0001836997,0.0004309639,0.0001569046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001322832,"about_ca_system_score_gemma":0.0002039773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001610334,"about_ca_topic_score_gemma":8.150054e-7,"domain_scores_codex":[0.9976929,0.0004612206,0.0008428876,0.0003459895,0.0001288296,0.0005282189],"domain_scores_gemma":[0.9989518,0.0001451558,0.000481009,0.0001874152,0.0001122649,0.0001223417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01402356,0.001351081,0.0002997898,0.00007662196,0.0004503115,0.0001215776,0.002701145,0.000009950129,0.9801831,0.0000275591,0.0003414489,0.0004139097],"study_design_scores_gemma":[0.007181312,0.003842626,0.000194161,0.00005969207,0.0001307844,0.0008397872,0.00313072,0.000009100566,0.9567916,0.00000261755,0.02751011,0.0003074717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9718105,0.02408398,0.00003360019,0.0003852204,0.002491495,0.0008505162,0.0000858698,0.00003016837,0.0002286315],"genre_scores_gemma":[0.9790401,0.0003109759,0.0003153056,0.001382559,0.0001461211,0.00004149496,0.000009846462,0.00004095568,0.01871257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02716866,"threshold_uncertainty_score":0.9999683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02093215928471416,"score_gpt":0.2879790633076734,"score_spread":0.2670469040229592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}