{"id":"W2954572909","doi":"10.1124/jpet.118.256016","title":"Experimental Autoimmune Encephalomyelitis Potentiates Mouse Mast Cell Protease 4–Dependent Pressor Responses to Centrally or Systemically Administered Big Endothelin-1","year":2019,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Multiple Sclerosis Society; Fonds de Recherche du Québec - Santé; Multiple Sclerosis Society of Canada; Université de Montréal; Université de Sherbrooke","keywords":"Medicine; Experimental autoimmune encephalomyelitis; Immunology; Mast cell; Endothelin receptor; Tumor necrosis factor alpha; Encephalomyelitis; Knockout mouse; Pharmacology; Endocrinology; Internal medicine; Immune system; Multiple sclerosis; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005393059,0.001726371,0.0009322601,0.0007639258,0.0003986132,0.0004656831,0.0003920429,0.000858541,0.003492075],"category_scores_gemma":[0.0004663655,0.0005935531,0.0008026379,0.0003406995,0.0009548185,0.0006395513,0.0004141447,0.003284188,0.0008500666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005278093,"about_ca_system_score_gemma":0.0005033759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006592856,"about_ca_topic_score_gemma":0.002246282,"domain_scores_codex":[0.9992911,0.0001426284,0.00005633327,0.00008849512,0.0001153698,0.0003061562],"domain_scores_gemma":[0.9993485,0.0001440683,0.0001504694,0.00006213871,0.00003112162,0.0002638147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004398487,0.0004061996,0.000269133,0.00007542205,0.00001479673,0.0002885518,0.00004380122,0.00008674644,0.9933701,0.00008919111,0.00008076317,0.0008768825],"study_design_scores_gemma":[0.0004794063,0.005660346,0.0103724,0.00002488752,0.00009526207,0.0004144283,0.00009968224,0.0006142724,0.9812392,0.0001007987,0.0008832474,0.00001609946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958739,0.00109153,0.000716529,0.0001848944,0.000200607,0.00005577934,0.0002871013,0.00009636132,0.001493395],"genre_scores_gemma":[0.9928368,0.001166623,0.001095526,0.0001718279,0.0002007269,0.0001353121,0.0004156285,0.00004319821,0.003934418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003492075,"threshold_uncertainty_score":0.01168221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02093215928471416,"score_gpt":0.2879790633076734,"score_spread":0.2670469040229592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}