{"id":"W2954585443","doi":"10.1158/0008-5472.can-18-3215","title":"An <i>ERG</i> Enhancer–Based Reporter Identifies Leukemia Cells with Elevated Leukemogenic Potential Driven by ERG-USP9X Feed-Forward Regulation","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Israel Science Foundation; Israel Cancer Research Fund","keywords":"Erg; Enhancer; Cancer research; Biology; Molecular biology; Genetics; Biochemistry; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002380342,0.0002949105,0.0002027303,0.0002728753,0.0001400039,0.0003497199,0.0001509786,0.0002649204,0.001125515],"category_scores_gemma":[0.00009393095,0.0001229921,0.0001918746,0.0001618502,0.0002692257,0.0001708967,0.0002273235,0.0004220283,0.000421122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003217646,"about_ca_system_score_gemma":0.0001731128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004235859,"about_ca_topic_score_gemma":0.0005518245,"domain_scores_codex":[0.9998548,0.00002406363,0.00001451316,0.00003788114,0.00004179797,0.0000268515],"domain_scores_gemma":[0.9999272,0.00001518956,0.00002504728,0.000009061814,0.000007762728,0.00001574421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000256807,0.000006573979,0.00009435618,0.000006091538,9.181082e-7,0.000008220875,0.000003747991,0.00002302626,0.999406,0.0000851398,0.00001290777,0.0003273043],"study_design_scores_gemma":[0.000004767292,0.00004789537,0.001363624,0.000001562441,0.000003565463,0.00008962757,0.00000758723,0.0007020964,0.9967396,0.00003111732,0.001006574,0.000001960729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9707066,0.0005660636,0.025107,0.0001725863,0.00002510171,0.00006851588,0.001211602,0.0003295516,0.001812908],"genre_scores_gemma":[0.982322,0.0003282544,0.01260055,0.00005129228,0.000006709181,0.00003806589,0.00151018,0.00005724229,0.003085582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001125515,"threshold_uncertainty_score":0.003765225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0106419136217504,"score_gpt":0.2965933236577974,"score_spread":0.285951410036047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}