{"id":"W2954606714","doi":"10.1158/1538-7445.am2019-ct129","title":"Abstract CT129: Identifying molecular determinants of response to apalutamide (APA) in patients (pts) with nonmetastatic castration-resistant prostate cancer (nmCRPC) in the SPARTAN study","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Prostate cancer; Medicine; Internal medicine; Oncology; Metastasis; Cancer; Proportional hazards model; Transcriptome; Biology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002557795,0.0002848925,0.000494303,0.0002517925,0.0001709334,0.0004485131,0.0002497447,0.0002307834,0.001389185],"category_scores_gemma":[0.0005998813,0.0001369371,0.0005263238,0.0005884419,0.0002137658,0.0002186824,0.000310836,0.0005018864,0.0002027807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000271747,"about_ca_system_score_gemma":0.00026398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001274057,"about_ca_topic_score_gemma":0.002342913,"domain_scores_codex":[0.9998011,0.00004583249,0.00001818936,0.00007095961,0.0000410357,0.00002288422],"domain_scores_gemma":[0.9996099,0.00004786086,0.0001381797,0.00003300729,0.00003604808,0.0001349366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01172711,0.0002070081,0.9709877,0.00008090722,0.0005025596,0.0001480551,0.0000455196,0.000344154,0.006657081,0.00004134189,0.0007927097,0.008465857],"study_design_scores_gemma":[0.0002983785,0.00142987,0.9956995,0.000005442582,0.0002526781,0.0003282768,0.00004727093,0.0005416195,0.0007654916,0.00006342663,0.0005599863,0.000007971031],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984118,0.00018661,0.0000590286,0.000037324,0.000006904529,0.00001498527,0.001030306,0.000005008772,0.0002479863],"genre_scores_gemma":[0.9978854,0.00006692868,0.0001043623,0.00003775395,0.0000149911,0.00001605869,0.001691662,0.000003475075,0.0001793287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001389185,"threshold_uncertainty_score":0.004647255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07130469458714175,"score_gpt":0.4347156962361843,"score_spread":0.3634110016490425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}