{"id":"W2954614475","doi":"10.1053/j.gastro.2019.06.037","title":"Effects of Ustekinumab on Histologic Disease Activity in Patients With Crohn’s Disease","year":2019,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"Janssen Research and Development; Atlantic Healthcare; Ferring Pharmaceuticals; Kyowa Hakko Kirin; Genentech; Janssen Scientific Affairs; Ipsen Biopharmaceuticals; Biogen; Tillotts Pharma; Boehringer Ingelheim; Janssen Pharmaceuticals; Gilead Sciences; Roche; Meso Scale Diagnostics; Johnson and Johnson; Takeda Pharmaceutical Company; AbbVie; Merck; Pfizer; Shire; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Ustekinumab; Medicine; Crohn's disease; Dermatology; Disease; Crohn disease; Gastroenterology; Internal medicine; Infliximab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000544034,0.0001966745,0.0002037714,0.00008398732,0.00001795947,0.000003963065,0.0001786579,0.0000667137,0.00002396264],"category_scores_gemma":[0.00005688187,0.0001709776,0.00008248701,0.0000346014,0.0001088482,0.000006098679,0.0000954253,0.00009800541,0.00002321685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004160235,"about_ca_system_score_gemma":0.00005995106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003525822,"about_ca_topic_score_gemma":0.00002332205,"domain_scores_codex":[0.9987335,0.0001974077,0.0001561364,0.000425985,0.0001429248,0.0003440516],"domain_scores_gemma":[0.9991584,0.000013578,0.0001255535,0.0004505334,0.00004950271,0.0002024771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03885616,0.0007400103,0.9579616,0.0001573376,0.00003154096,0.0002010651,0.000006663892,0.0002682396,0.001575184,0.0000159351,0.00009063019,0.00009560915],"study_design_scores_gemma":[0.004703181,0.001229701,0.9935368,0.00003235557,0.00003170686,3.408329e-7,0.000001344023,0.00002419112,0.00027533,0.00001130925,0.00005122866,0.000102531],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990084,0.00001733471,0.00004574149,0.00004115923,0.0001501502,0.0006395174,0.00004274155,0.000009464261,0.00004555364],"genre_scores_gemma":[0.9993334,0.000003021634,0.00002227053,0.0003916755,0.00002434711,0.00005759337,0.00007098604,0.00002178564,0.00007491874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03557516,"threshold_uncertainty_score":0.6972266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.001987984356629027,"score_gpt":0.1797431397050483,"score_spread":0.1777551553484193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}