{"id":"W2954778422","doi":"10.1158/1538-7445.am2019-2198","title":"Abstract 2198: PBI-200: A novel, brain penetrant, next generation pan-TRK kinase inhibitor","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Paraza Pharma (Canada)","funders":"","keywords":"Trk receptor; Tropomyosin receptor kinase A; Cancer research; Kinase; Tyrosine kinase; Receptor tyrosine kinase; Anaplastic lymphoma kinase; Crizotinib; Biology; Medicine; Internal medicine; Signal transduction; Lung cancer; Receptor; Cell biology; Neurotrophin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001082519,0.0001812183,0.0003002693,0.0002581512,0.0001484792,0.0001227048,0.0001718514,0.0001595949,0.005705823],"category_scores_gemma":[0.00006009776,0.000159296,0.0001095847,0.0004955499,0.000081135,0.0001968022,0.00005214957,0.0006493329,0.0004583548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004790201,"about_ca_system_score_gemma":0.0008394639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00188251,"about_ca_topic_score_gemma":0.0005873195,"domain_scores_codex":[0.9975495,0.00006616996,0.0002719318,0.0005333889,0.000939156,0.0006398683],"domain_scores_gemma":[0.9986911,0.0001030908,0.00005239582,0.000540757,0.0003568363,0.0002558114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000367069,0.0001468702,0.0003612853,0.0001375517,0.00004499285,0.00003224028,0.0003057966,0.00001404564,0.9545608,0.0007108605,0.01276925,0.03054926],"study_design_scores_gemma":[0.007515075,0.001247661,0.01102082,0.0005321533,0.00002355122,0.00002967526,0.0004557591,0.0007806935,0.7622964,0.0002710893,0.2153759,0.000451165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878906,0.002810862,0.0001793127,0.00503533,0.000758352,0.001160909,0.00004777516,0.00005230881,0.002064524],"genre_scores_gemma":[0.9878961,0.0007669349,0.0001909172,0.001072327,0.002387126,0.0002151208,0.00005151561,0.00006471392,0.007355268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2026067,"threshold_uncertainty_score":0.9952031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1588392718518351,"score_gpt":0.4169846002086986,"score_spread":0.2581453283568635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}