{"id":"W2954778422","doi":"10.1158/1538-7445.am2019-2198","title":"Abstract 2198: PBI-200: A novel, brain penetrant, next generation pan-TRK kinase inhibitor","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Paraza Pharma (Canada)","funders":"","keywords":"Trk receptor; Tropomyosin receptor kinase A; Cancer research; Kinase; Tyrosine kinase; Receptor tyrosine kinase; Anaplastic lymphoma kinase; Crizotinib; Biology; Medicine; Internal medicine; Signal transduction; Lung cancer; Receptor; Cell biology; Neurotrophin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007054549,0.0005358832,0.0002696411,0.0002912512,0.0001132765,0.000231378,0.0004481928,0.0003523476,0.004095323],"category_scores_gemma":[0.00005538293,0.0001567628,0.0001524603,0.0002136523,0.0001314355,0.000213439,0.0001863359,0.0008097146,0.002173826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003217793,"about_ca_system_score_gemma":0.0003131951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000597515,"about_ca_topic_score_gemma":0.001094361,"domain_scores_codex":[0.9999428,0.000005838041,0.000003126578,0.00001370152,0.00001781619,0.00001681539],"domain_scores_gemma":[0.9999766,0.000002012691,0.000004177251,0.000001757671,0.000003375577,0.00001206496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001285463,0.0006075556,0.0005081946,0.0003424521,0.00003526977,0.000710791,0.00003565531,0.0008817872,0.8854358,0.0009216355,0.01403257,0.09520286],"study_design_scores_gemma":[0.001525277,0.00647166,0.006242103,0.00005070543,0.0001148807,0.008686305,0.00002306781,0.003919538,0.8669101,0.0003506174,0.1056636,0.00004214567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8631576,0.03098592,0.02070975,0.001956804,0.0005224325,0.0007418673,0.006155369,0.003339229,0.07243106],"genre_scores_gemma":[0.9385264,0.01014855,0.01017106,0.0009434525,0.000104906,0.0003602676,0.007137796,0.0001054181,0.03250207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004095323,"threshold_uncertainty_score":0.01370019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1588392718518351,"score_gpt":0.4169846002086986,"score_spread":0.2581453283568635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}