{"id":"W2954785163","doi":"10.1016/j.cell.2019.06.001","title":"Pervasive Chromatin-RNA Binding Protein Interactions Enable RNA-Based Regulation of Transcription","year":2019,"lang":"en","type":"article","venue":"Cell","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":419,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; National Human Genome Research Institute; Wuhan University; National Natural Science Foundation of China","keywords":"Biology; Chromatin; RNA-binding protein; RNA splicing; Genetics; Promoter; Transcription (linguistics); ChIA-PET; RNA; Transcription factor; Computational biology; Regulation of gene expression; Transcriptional regulation; Gene; Chromatin remodeling; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004234884,0.0003348719,0.0003560123,0.0003597533,0.0005119265,0.001399203,0.0004682698,0.0004813645,0.002151549],"category_scores_gemma":[0.0004651286,0.0003139006,0.0003259382,0.0003304245,0.000845996,0.0007317383,0.001229866,0.00121276,0.0009773504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004448822,"about_ca_system_score_gemma":0.0002977949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003287889,"about_ca_topic_score_gemma":0.001087424,"domain_scores_codex":[0.9996098,0.00004727377,0.00001583429,0.0001280261,0.0001273543,0.00007169714],"domain_scores_gemma":[0.9997123,0.00007803435,0.00003871389,0.00006436228,0.00002724878,0.00007926571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004605997,0.000007856468,0.0002986331,0.00001775792,0.000004004236,0.00007099777,0.00002698351,0.00007448077,0.992076,0.004492851,0.00009596895,0.002788356],"study_design_scores_gemma":[0.0000124061,0.00006215294,0.004703055,0.000007605045,0.00001545696,0.0005299215,0.00007559401,0.001583751,0.9812146,0.003210966,0.008573839,0.0000106753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8593812,0.008202512,0.1114499,0.001431031,0.0004019239,0.00005360904,0.0006626469,0.001123571,0.01729361],"genre_scores_gemma":[0.9829766,0.001042898,0.01108196,0.000219012,0.00006803919,0.00001398221,0.000294424,0.00009271517,0.004210283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002151549,"threshold_uncertainty_score":0.007197618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01213616431612615,"score_gpt":0.2471469800560293,"score_spread":0.2350108157399031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}