{"id":"W2954811145","doi":"10.1158/1538-7445.am2019-ct183","title":"Abstract CT183: Phase (Ph) I/II study of MBG453± spartalizumab (PDR001) in patients (pts) with advanced malignancies","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Internal medicine; Adverse effect; Cancer; Pancreatic cancer; Gastroenterology; Toxicity; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001090757,0.001154349,0.0009242575,0.0002604185,0.0002764184,0.0007087231,0.0005196515,0.0006252549,0.003012269],"category_scores_gemma":[0.000532068,0.0003589409,0.0007743432,0.0003195553,0.0004374342,0.0003290965,0.0002648111,0.001802566,0.0008587079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001021282,"about_ca_system_score_gemma":0.00174995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001680287,"about_ca_topic_score_gemma":0.002766247,"domain_scores_codex":[0.9997532,0.000111676,0.00001339277,0.00004630751,0.00003108412,0.00004441745],"domain_scores_gemma":[0.9996802,0.00003674364,0.00006265366,0.00002096351,0.00001934655,0.0001802112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6141075,0.04546649,0.03171955,0.0008270957,0.001042598,0.0004387564,0.0003586398,0.00786146,0.1368057,0.0004994615,0.009966969,0.1509057],"study_design_scores_gemma":[0.4358682,0.4906401,0.04204556,0.00005407241,0.0006615452,0.0006843735,0.00006319812,0.004429484,0.01758754,0.0002750554,0.007655708,0.0000351093],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914169,0.001207982,0.0008055727,0.0003273128,0.00004112262,0.00228794,0.00179146,0.0001133147,0.002008499],"genre_scores_gemma":[0.9883462,0.0008467073,0.00205448,0.0006269001,0.00008264881,0.001574947,0.003671531,0.00003717703,0.002759496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003012269,"threshold_uncertainty_score":0.01007706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0518266288122539,"score_gpt":0.4116926234289976,"score_spread":0.3598659946167437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}