{"id":"W2954831331","doi":"10.1093/hmg/ddz161","title":"A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity","year":2019,"lang":"en","type":"review","venue":"Human Molecular Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Impact; McMaster University; University of Toronto","funders":"Carolina Population Center, University of North Carolina at Chapel Hill; National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Human Genome Research Institute; National Institute on Drug Abuse; NIHR Cambridge Biomedical Research Centre; Cambridge Institute for Medical Research, University of Cambridge; Medical Research Council; Canadian Institutes of Health Research; Manchester Biomedical Research Centre; Agricultural Research Service; Terveyden ja hyvinvoinnin laitos; Government of Western Australia; Paavo Nurmen Säätiö; National Center for Research Resources; Diabetesliitto; Queen's University; Universitetet i Bergen; Emil Aaltosen Säätiö; Asthma and Lung UK; Vetenskapsrådet; Great Ormond Street Hospital for Children; National Health and Medical Research Council; Edith Cowan University; Suomen Kulttuurirahasto; Oulun Yliopisto; University of Toronto; Consejo Nacional de Ciencia y Tecnología; Australian Government; Norges Forskningsråd; Erasmus Medisch Centrum; Strategiske Forskningsråd; ZonMw; European Commission; Socialdepartementet; Deutsche Forschungsgemeinschaft; Murdoch University; Sydäntutkimussäätiö; Curtin University of Technology; Kela; Bergens Forskningsstiftelse; Raine Medical Research Foundation; Kuopion Yliopistollinen Sairaala; H. Lundbeck A/S; University of Bristol; National Cancer Institute; Lundbeckfonden; University College London; Wellcome Trust; National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Government of Ontario; Tays; Steno Diabetes Center Copenhagen; Juvenile Diabetes Research Foundation International; Compute Canada; Foundation for Cardiovascular Research; National Heart, Lung, and Blood Institute; Itä-Suomen Yliopisto; Southern California Environmental Health Sciences Center; National Institutes of Health; Stiftelsen Kristian Gerhard Jebsen; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Signe ja Ane Gyllenbergin Säätiö; Tampereen Tuberkuloosisäätiö; Heart and Stroke Foundation of Canada; Yrjö Jahnssonin Säätiö; University of Notre Dame; American Diabetes Association; Juho Vainion Säätiö; Novo Nordisk Fonden; American Heart Association; U.S. Department of Agriculture","keywords":"Biology; Locus (genetics); Genetics; Genome-wide association study; Single-nucleotide polymorphism; Childhood obesity; Obesity; Genetic association; Body mass index; Evolutionary biology; Gene; Overweight; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009601509,0.001515451,0.001895589,0.003368253,0.0009727097,0.002172754,0.001086622,0.0009334561,0.002212995],"category_scores_gemma":[0.01136865,0.0006199867,0.008596682,0.003781241,0.0006893773,0.0006530085,0.001821363,0.001946975,0.0002167304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004973182,"about_ca_system_score_gemma":0.0007454313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004607665,"about_ca_topic_score_gemma":0.008368712,"domain_scores_codex":[0.9936908,0.002829131,0.0007389734,0.001849469,0.0005164625,0.0003751226],"domain_scores_gemma":[0.9913912,0.004433508,0.0009458291,0.00215722,0.0006439917,0.0004283003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.004965271,0.00004564549,0.7832255,0.001554926,0.1768147,0.002083763,0.0005359842,0.001727927,0.0101956,0.0009587669,0.0007578018,0.01713412],"study_design_scores_gemma":[0.0004479268,0.0006671919,0.7524725,0.0005589055,0.2285741,0.003291907,0.0005588336,0.005185448,0.002538002,0.002177934,0.003456571,0.0000707349],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9195069,0.06021144,0.01520469,0.001201543,0.0002063475,0.00007267372,0.001797256,0.0002673615,0.00153183],"genre_scores_gemma":[0.994148,0.002643246,0.002230889,0.0001643585,0.00005785997,0.0000212233,0.0005115795,0.00004082239,0.0001820285],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.009601509,"threshold_uncertainty_score":0.05077821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09970799683140308,"score_gpt":0.3518054437935898,"score_spread":0.2520974469621867,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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