{"id":"W2954831331","doi":"10.1093/hmg/ddz161","title":"A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity","year":2019,"lang":"en","type":"review","venue":"Human Molecular Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Impact; McMaster University; University of Toronto","funders":"Carolina Population Center, University of North Carolina at Chapel Hill; National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Human Genome Research Institute; National Institute on Drug Abuse; NIHR Cambridge Biomedical Research Centre; Cambridge Institute for Medical Research, University of Cambridge; Medical Research Council; Canadian Institutes of Health Research; Manchester Biomedical Research Centre; Agricultural Research Service; Terveyden ja hyvinvoinnin laitos; Government of Western Australia; Paavo Nurmen Säätiö; National Center for Research Resources; Diabetesliitto; Queen's University; Universitetet i Bergen; Emil Aaltosen Säätiö; Asthma and Lung UK; Vetenskapsrådet; Great Ormond Street Hospital for Children; National Health and Medical Research Council; Edith Cowan University; Suomen Kulttuurirahasto; Oulun Yliopisto; University of Toronto; Consejo Nacional de Ciencia y Tecnología; Australian Government; Norges Forskningsråd; Erasmus Medisch Centrum; Strategiske Forskningsråd; ZonMw; European Commission; Socialdepartementet; Deutsche Forschungsgemeinschaft; Murdoch University; Sydäntutkimussäätiö; Curtin University of Technology; Kela; Bergens Forskningsstiftelse; Raine Medical Research Foundation; Kuopion Yliopistollinen Sairaala; H. Lundbeck A/S; University of Bristol; National Cancer Institute; Lundbeckfonden; University College London; Wellcome Trust; National Institute for Health and Care Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Government of Ontario; Tays; Steno Diabetes Center Copenhagen; Juvenile Diabetes Research Foundation International; Compute Canada; Foundation for Cardiovascular Research; National Heart, Lung, and Blood Institute; Itä-Suomen Yliopisto; Southern California Environmental Health Sciences Center; National Institutes of Health; Stiftelsen Kristian Gerhard Jebsen; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Signe ja Ane Gyllenbergin Säätiö; Tampereen Tuberkuloosisäätiö; Heart and Stroke Foundation of Canada; Yrjö Jahnssonin Säätiö; University of Notre Dame; American Diabetes Association; Juho Vainion Säätiö; Novo Nordisk Fonden; American Heart Association; U.S. Department of Agriculture","keywords":"Biology; Locus (genetics); Genetics; Genome-wide association study; Single-nucleotide polymorphism; Childhood obesity; Obesity; Genetic association; Body mass index; Evolutionary biology; Gene; Overweight; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001348831,0.0008418516,0.005907678,0.0003637716,0.0001549618,0.00003128435,0.0006354699,0.001089005,0.00005749373],"category_scores_gemma":[0.0009501331,0.0006956452,0.003977429,0.000888343,0.0001433706,0.000003517669,0.0001395119,0.0003888539,0.000007004889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002226768,"about_ca_system_score_gemma":0.0003033108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001092416,"about_ca_topic_score_gemma":0.0001701206,"domain_scores_codex":[0.9949045,0.001196163,0.00156087,0.001092653,0.0005500081,0.0006958007],"domain_scores_gemma":[0.9951043,0.0003911843,0.002572271,0.001162126,0.0006417803,0.0001283921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.000007016667,0.0006158195,0.01069898,0.001623759,0.9794196,0.00001400304,0.00022136,0.004372715,0.0002820882,0.0000281143,0.001209769,0.001506784],"study_design_scores_gemma":[0.0005754033,0.00081496,0.03969888,0.0002052252,0.8572196,0.000003428079,0.00006387174,0.00000798752,0.00003838298,0.0001343534,0.09990103,0.001336898],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02938969,0.9680057,0.0006850315,0.00003876063,0.00005582442,0.001111719,0.0004972206,0.00001782147,0.000198262],"genre_scores_gemma":[0.04296289,0.9497082,0.0008323895,0.0003074244,0.00007294333,0.0001778051,0.004632911,0.0001265284,0.001178905],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1222,"threshold_uncertainty_score":0.9995494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09970799683140308,"score_gpt":0.3518054437935898,"score_spread":0.2520974469621867,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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