{"id":"W2954856780","doi":"10.1101/692004","title":"Genetic immunodeficiency and autoimmune disease reveal distinct roles of Hem1 in the WAVE2 and mTORC2 complexes","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba","funders":"","keywords":"Biology; Immunodeficiency; Autoimmunity; Primary immunodeficiency; Immunology; Immune system; T cell; Cytokine; Wiskott–Aldrich syndrome protein; Suppressor of cytokine signaling 1; Cell biology; mTORC2; PI3K/AKT/mTOR pathway; Actin cytoskeleton; Genetics; Signal transduction; Cell; Gene; mTORC1; Suppressor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001190064,0.0004110366,0.0001701984,0.0003671066,0.0001636611,0.0003599442,0.0002080159,0.0004471498,0.001780932],"category_scores_gemma":[0.0001224362,0.0001442849,0.0001403023,0.0001357761,0.0002704807,0.0001622832,0.0002878587,0.0004505552,0.000519898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002993676,"about_ca_system_score_gemma":0.0001074993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002827556,"about_ca_topic_score_gemma":0.0003444456,"domain_scores_codex":[0.9999036,0.00001319899,0.000009810719,0.00002367972,0.00003157421,0.00001815807],"domain_scores_gemma":[0.9999129,0.00001954793,0.00003131747,0.000008955584,0.000006291445,0.00002094205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002094977,0.00001131204,0.002676361,0.00004134221,0.00001154239,0.0008877117,0.00001983875,0.0001284522,0.9928537,0.0005806574,0.0002954233,0.002284101],"study_design_scores_gemma":[0.00003515417,0.0000864633,0.0489619,0.00001643528,0.00003760839,0.006162264,0.00005228518,0.002408234,0.9353141,0.0006430112,0.006273193,0.000009470527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914808,0.002395062,0.002273554,0.0003451899,0.0000358028,0.000008154946,0.0005028815,0.0001102898,0.002848124],"genre_scores_gemma":[0.9951463,0.0004442569,0.001212159,0.00007734538,0.00001804719,0.000008944246,0.0006594149,0.00002748052,0.002406029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001780932,"threshold_uncertainty_score":0.005957782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008518052545182427,"score_gpt":0.203917988111443,"score_spread":0.1953999355662605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}