{"id":"W2954856780","doi":"10.1101/692004","title":"Genetic immunodeficiency and autoimmune disease reveal distinct roles of Hem1 in the WAVE2 and mTORC2 complexes","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba","funders":"","keywords":"Biology; Immunodeficiency; Autoimmunity; Primary immunodeficiency; Immunology; Immune system; T cell; Cytokine; Wiskott–Aldrich syndrome protein; Suppressor of cytokine signaling 1; Cell biology; mTORC2; PI3K/AKT/mTOR pathway; Actin cytoskeleton; Genetics; Signal transduction; Cell; Gene; mTORC1; Suppressor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007835106,0.0006088261,0.0008620885,0.0002604486,0.0002864314,0.00009671444,0.0008865616,0.0004590596,0.00003603702],"category_scores_gemma":[0.0001902646,0.0005083703,0.0001545306,0.0003186471,0.0009723697,0.0001025117,0.00063179,0.0009802525,0.00002466791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005250071,"about_ca_system_score_gemma":0.0003174324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002929592,"about_ca_topic_score_gemma":0.000003386913,"domain_scores_codex":[0.9970152,0.0004630263,0.0008603041,0.0008741111,0.0001361419,0.0006511589],"domain_scores_gemma":[0.9976854,0.0002220957,0.0005171123,0.001409347,0.0001435902,0.00002241589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002374267,0.0005680275,0.05393528,0.0009248693,0.0001917017,0.00002523869,0.0004014513,0.00008746202,0.9421523,0.001332348,0.00006951022,0.00007436316],"study_design_scores_gemma":[0.001107841,0.00007946618,0.98635,0.0005458802,0.000156657,1.640366e-7,0.00008723147,0.000109338,0.008737984,0.00001978319,0.002183318,0.00062232],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8110051,0.1871163,0.00006712266,0.0001670188,0.0005237863,0.0007319069,0.000308617,0.00006905702,0.00001112299],"genre_scores_gemma":[0.9982553,0.001401722,0.00006323619,0.00009458263,0.000009344114,0.00009624023,0.000003663898,0.00005953591,0.0000164068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9334143,"threshold_uncertainty_score":0.9997368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008518052545182427,"score_gpt":0.203917988111443,"score_spread":0.1953999355662605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}