{"id":"W2954857179","doi":"10.1093/toxsci/kfz147","title":"Gestational and Lactational Exposure to an Environmentally Relevant Mixture of Brominated Flame Retardants Downregulates Junctional Proteins, Thyroid Hormone Receptor α1 Expression, and the Proliferation-Apoptosis Balance in Mammary Glands Post Puberty","year":2019,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Health Canada; Institut National de la Recherche Scientifique","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Health Canada","keywords":"Internal medicine; Endocrinology; Lactation; Biology; Thyroid; Hormone; Thyroid hormone receptor; Adherens junction; Receptor; Pregnancy; Cell; Cadherin; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001182219,0.0002605297,0.0003003995,0.0002587188,0.0001701243,0.0002324649,0.0001482676,0.0002465399,0.001169436],"category_scores_gemma":[0.0001299068,0.0002050847,0.0002736768,0.0001303238,0.0002042507,0.0001816788,0.0001723944,0.0005708514,0.0001695855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002746641,"about_ca_system_score_gemma":0.000265294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001195416,"about_ca_topic_score_gemma":0.002091326,"domain_scores_codex":[0.9998192,0.00002484994,0.00001416828,0.00005006841,0.00004613195,0.0000455394],"domain_scores_gemma":[0.9998761,0.00001222377,0.00004160692,0.0000114369,0.0000163749,0.00004220913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000542909,0.00006635295,0.0009059177,0.00001553578,0.000007520197,0.00003953528,0.00002956609,0.00001248385,0.9972555,0.0000204657,0.00001965799,0.001084625],"study_design_scores_gemma":[0.00003348953,0.00296941,0.04918903,0.00001245243,0.0000629717,0.0003118834,0.0002017771,0.0003489736,0.944728,0.00005421784,0.002078314,0.000009650431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972444,0.00121168,0.0008079254,0.00007714731,0.00002603296,0.000009334758,0.0001608785,0.00002902738,0.0004337137],"genre_scores_gemma":[0.9925759,0.00127054,0.001000326,0.00009161371,0.0000125361,0.00004210468,0.0003567105,0.00001416871,0.004636056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001195416,"threshold_uncertainty_score":0.003912151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005595802951772965,"score_gpt":0.207898784735611,"score_spread":0.2023029817838381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}