{"id":"W2954857179","doi":"10.1093/toxsci/kfz147","title":"Gestational and Lactational Exposure to an Environmentally Relevant Mixture of Brominated Flame Retardants Downregulates Junctional Proteins, Thyroid Hormone Receptor α1 Expression, and the Proliferation-Apoptosis Balance in Mammary Glands Post Puberty","year":2019,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Health Canada; Institut National de la Recherche Scientifique","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Health Canada","keywords":"Internal medicine; Endocrinology; Lactation; Biology; Thyroid; Hormone; Thyroid hormone receptor; Adherens junction; Receptor; Pregnancy; Cell; Cadherin; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001036804,0.0001806393,0.0002306175,0.00005123288,0.0002185421,0.00008126953,0.000340805,0.0001212822,0.001104938],"category_scores_gemma":[0.0003588564,0.0001021657,0.0000238831,0.0003579091,0.0009175346,0.0006833239,0.0002290174,0.0001570857,0.00003318207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009428056,"about_ca_system_score_gemma":0.0000510285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002447791,"about_ca_topic_score_gemma":0.00004525156,"domain_scores_codex":[0.9978628,0.0002490737,0.0003662282,0.0005388552,0.0006824424,0.0003005568],"domain_scores_gemma":[0.9992443,0.0002634491,0.0001587519,0.0001606729,0.000007831331,0.0001650514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003789203,0.0001362848,0.07856198,0.000003257989,0.000005284678,9.113161e-7,0.0005609164,0.0002362215,0.9170929,0.0001727939,0.0001199322,0.002730658],"study_design_scores_gemma":[0.001130514,0.001108714,0.9805356,0.00001892443,0.000004186111,0.00001861259,0.0002328265,0.0009218959,0.01488819,0.0009118295,0.00005795846,0.0001707478],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994184,0.0001072724,0.00003696317,0.004456099,0.00004895769,0.0008119558,0.00009430077,0.00001923367,0.000241227],"genre_scores_gemma":[0.9933893,0.00005179693,0.00577998,0.0005061958,0.00002114762,0.00004362008,0.00001529911,0.000005819164,0.0001868265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9022046,"threshold_uncertainty_score":0.9998082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005595802951772965,"score_gpt":0.207898784735611,"score_spread":0.2023029817838381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}