{"id":"W2954917855","doi":"10.1158/1538-7445.am2019-ct043","title":"Abstract CT043: Outcomes among patients (pts) with metastatic nonsquamous NSCLC with liver metastases or brain metastases treated with pembrolizumab (pembro) plus pemetrexed-platinum: Results from the KEYNOTE-189 study","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Health Sciences Centre; Hôpital Charles-Le Moyne","funders":"","keywords":"Pemetrexed; Medicine; Carboplatin; Internal medicine; Placebo; Oncology; Lung cancer; Randomization; Cisplatin; Clinical endpoint; Pembrolizumab; Randomized controlled trial; Chemotherapy; Cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001807686,0.001051802,0.001843758,0.0005528594,0.0006283185,0.0003377203,0.0006947619,0.000109047,0.00220796],"category_scores_gemma":[0.0006813553,0.0004614854,0.0002386432,0.00203485,0.0007783558,0.0004985174,0.0002442863,0.001242958,0.0002043712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008657333,"about_ca_system_score_gemma":0.001536348,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.05631166,"about_ca_topic_score_gemma":0.03167433,"domain_scores_codex":[0.990527,0.001428186,0.0009687405,0.001837057,0.00368115,0.001557879],"domain_scores_gemma":[0.9898963,0.005392171,0.0005175257,0.002298489,0.001238867,0.0006566485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.14303,0.008018001,0.7965907,0.0003920934,0.01471809,0.006033174,0.00456531,0.001245974,0.0001435239,0.00003311891,0.00869846,0.01653161],"study_design_scores_gemma":[0.1032758,0.01877359,0.8618433,0.0009764929,0.003386893,0.00006461984,0.008131742,0.0001434677,0.001042443,0.000007036087,0.00148029,0.0008743164],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848391,0.0007274012,0.00003373808,0.0008778966,0.00006812522,0.008791077,0.00391997,0.0001438768,0.0005988603],"genre_scores_gemma":[0.9920775,0.00008744084,0.001140429,0.0003322555,0.00009360126,0.001280007,0.001242459,0.0002294447,0.00351685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06525263,"threshold_uncertainty_score":0.9997837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07111186119183589,"score_gpt":0.3649071305933858,"score_spread":0.2937952694015499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}