{"id":"W2954917855","doi":"10.1158/1538-7445.am2019-ct043","title":"Abstract CT043: Outcomes among patients (pts) with metastatic nonsquamous NSCLC with liver metastases or brain metastases treated with pembrolizumab (pembro) plus pemetrexed-platinum: Results from the KEYNOTE-189 study","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Health Sciences Centre; Hôpital Charles-Le Moyne","funders":"","keywords":"Pemetrexed; Medicine; Carboplatin; Internal medicine; Placebo; Oncology; Lung cancer; Randomization; Cisplatin; Clinical endpoint; Pembrolizumab; Randomized controlled trial; Chemotherapy; Cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001518395,0.000705806,0.001168704,0.0003226552,0.0002852921,0.0006309397,0.0009176115,0.0009787729,0.003245097],"category_scores_gemma":[0.001510446,0.0003052794,0.002329728,0.0009501287,0.0004382974,0.0007097198,0.0004657379,0.00141569,0.0004727794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009089321,"about_ca_system_score_gemma":0.0009766588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002328721,"about_ca_topic_score_gemma":0.0037981,"domain_scores_codex":[0.9991896,0.0004700375,0.00006266163,0.0001202096,0.0000898729,0.00006762194],"domain_scores_gemma":[0.9983401,0.0002599899,0.0006980368,0.0001574942,0.0001233524,0.0004210779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8022147,0.002830059,0.1613148,0.0008045214,0.005967935,0.0002461094,0.00009108817,0.001238682,0.006368465,0.00009031436,0.003234977,0.01559829],"study_design_scores_gemma":[0.2580856,0.1133188,0.6107641,0.0001559018,0.008540088,0.0007966765,0.0001159584,0.001727031,0.002917806,0.0002546162,0.003240576,0.00008277802],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901281,0.001978866,0.0002045815,0.0001835061,0.00003752501,0.0003247991,0.006359234,0.00002202712,0.0007613549],"genre_scores_gemma":[0.9894684,0.000478683,0.0002408349,0.0002399566,0.00009293333,0.000303842,0.00860889,0.000006570578,0.0005598987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003245097,"threshold_uncertainty_score":0.01085591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07111186119183589,"score_gpt":0.3649071305933858,"score_spread":0.2937952694015499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}