{"id":"W2954925281","doi":"10.1158/1538-7445.sabcs18-2998","title":"Abstract 2998: Co-targeting bulk tumor and CSCs in clinically translatable TNBC patient-derived xenografts via combination nanotherapy","year":2019,"lang":"en","type":"article","venue":"Experimental and Molecular Therapeutics","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Triple-negative breast cancer; Cancer research; Wnt signaling pathway; Medicine; Cancer stem cell; Breast cancer; Cancer; Paclitaxel; Medulloblastoma; Chemistry; Internal medicine; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000083433,0.0002568374,0.000241196,0.0001624454,0.00008282263,0.0001940214,0.0001586843,0.0002869003,0.001054604],"category_scores_gemma":[0.00008167627,0.00009269518,0.0001739802,0.0001021564,0.000105776,0.0001697476,0.000138247,0.0003587955,0.0003183842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002424884,"about_ca_system_score_gemma":0.0001636952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004697398,"about_ca_topic_score_gemma":0.0009595051,"domain_scores_codex":[0.9999086,0.00001125438,0.000005125908,0.00002047343,0.00003847931,0.00001604647],"domain_scores_gemma":[0.9999679,0.000005164708,0.000008624598,0.000004002679,0.000006771584,0.000007564016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007167113,0.00004471271,0.000106278,0.00003918283,0.000005528793,0.00004379109,0.00001242505,0.0001782621,0.9932862,0.0001101199,0.0001721569,0.005929712],"study_design_scores_gemma":[0.00003147959,0.0005179184,0.0009051784,0.000005066796,0.00001726404,0.0004602938,0.00000908394,0.002008131,0.990925,0.00003734833,0.005078029,0.000005368001],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779382,0.002514838,0.01394833,0.0002445958,0.00008067884,0.0001158553,0.0003280873,0.0002480253,0.004581506],"genre_scores_gemma":[0.9868618,0.001052216,0.00656961,0.00008069176,0.00001552823,0.00008856722,0.0002906249,0.00004540184,0.004995523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001054604,"threshold_uncertainty_score":0.003528059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01127026259689328,"score_gpt":0.3037540037524735,"score_spread":0.2924837411555802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}