{"id":"W2954925281","doi":"10.1158/1538-7445.sabcs18-2998","title":"Abstract 2998: Co-targeting bulk tumor and CSCs in clinically translatable TNBC patient-derived xenografts via combination nanotherapy","year":2019,"lang":"en","type":"article","venue":"Experimental and Molecular Therapeutics","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Triple-negative breast cancer; Cancer research; Wnt signaling pathway; Medicine; Cancer stem cell; Breast cancer; Cancer; Paclitaxel; Medulloblastoma; Chemistry; Internal medicine; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009707743,0.0001845333,0.0001639971,0.00004202304,0.00006214424,0.00005061083,0.00007698774,0.00008886054,0.00003083749],"category_scores_gemma":[0.000002364569,0.0001740356,0.00005705864,0.00004847294,0.00008263766,0.000011647,0.00004077303,0.00009864536,0.000005484038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002030428,"about_ca_system_score_gemma":0.00003200294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009631319,"about_ca_topic_score_gemma":0.000009350618,"domain_scores_codex":[0.9989126,0.00005187085,0.0002391829,0.0003574747,0.0001601294,0.0002786905],"domain_scores_gemma":[0.9996485,0.00001049399,0.00006541576,0.0001622128,0.00002363919,0.00008970463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004075918,0.0003303489,0.004836002,0.00001416327,0.00008494746,0.00002146492,0.0003379235,0.000003414919,0.9878414,0.00001512294,0.00001061297,0.006096983],"study_design_scores_gemma":[0.002795542,0.001282912,0.001756109,0.0000184407,0.000006802144,0.00001089199,0.0002407782,0.00006829893,0.9883614,0.00005500933,0.005190707,0.0002130888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891674,0.009804731,0.00008760085,0.00007066823,0.0000682616,0.0004547453,0.00001507715,0.000009361273,0.0003221725],"genre_scores_gemma":[0.998183,0.0005583162,0.0002692631,0.0007497685,0.00001960864,0.0000368947,0.0001326681,0.00003037603,0.00002015611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009246415,"threshold_uncertainty_score":0.7096964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01127026259689328,"score_gpt":0.3037540037524735,"score_spread":0.2924837411555802,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}