{"id":"W2954939931","doi":"10.1021/acschembio.9b00247","title":"Triggered Release Enhances the Cytotoxicity of Stable Colloidal Drug Aggregates","year":2019,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada","keywords":"Colloid; Cytotoxicity; Internalization; Endosome; Chemistry; Endocytosis; Biophysics; Drug; Biochemistry; Intracellular; Pharmacology; Cell; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001129949,0.0002366344,0.0001916039,0.0001376746,0.0001039514,0.0003420323,0.0001486384,0.0003207297,0.0009338261],"category_scores_gemma":[0.0001864319,0.0001196128,0.0001676272,0.00008070331,0.0001366461,0.0001888461,0.0002163876,0.0003451749,0.0004037909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002835233,"about_ca_system_score_gemma":0.0001553287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004271275,"about_ca_topic_score_gemma":0.0004760991,"domain_scores_codex":[0.9998425,0.00001524173,0.00001285251,0.00003669525,0.00006495534,0.00002769834],"domain_scores_gemma":[0.9998922,0.00002304716,0.00002755652,0.0000130039,0.00002613347,0.00001809838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001920156,0.000006978063,0.00002404581,0.00000892713,0.000001773082,0.00002282017,0.000006965875,0.00004956275,0.9991008,0.00003265975,0.00002536502,0.0007009391],"study_design_scores_gemma":[0.000007218238,0.00009744417,0.0003949593,0.000001113877,0.000003881771,0.00006101885,0.00000210017,0.0008710599,0.998063,0.00001343063,0.0004823282,0.00000237313],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910363,0.0008470813,0.005555346,0.0001017036,0.00003018272,0.00003110034,0.0001034992,0.0001661117,0.002128752],"genre_scores_gemma":[0.9950211,0.0002494531,0.002188534,0.00006130158,0.00001107661,0.00002230993,0.0000922108,0.0000413876,0.002312707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009338261,"threshold_uncertainty_score":0.003123939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005370371425290687,"score_gpt":0.2481827244764433,"score_spread":0.2428123530511526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}