{"id":"W2954967239","doi":"10.1038/s41598-019-45896-4","title":"Common BACE2 Polymorphisms are Associated with Altered Risk for Alzheimer’s Disease and CSF Amyloid Biomarkers in APOE ε4 Non-Carriers","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, Los Angeles; Eurostars; Genentech; UK Dementia Research Institute; H. Lundbeck A/S; Servier; University of Southern California; University College London; Eisai; Parkinson's UK; Northern California Institute for Research and Education; Johns Hopkins University; Pfizer; Biogen; University of Miami; BioClinica; National Institutes of Health; Rosetrees Trust; Alzheimer's Disease Neuroimaging Initiative; Eli Lilly and Company; U.S. Department of Defense; Medical Research Council; Meso Scale Diagnostics; F. Hoffmann-La Roche; Bristol-Myers Squibb; Alzheimer's Society; Novartis Pharmaceuticals Corporation; U.S. Department of Health and Human Services; Foundation for the National Institutes of Health","keywords":"Single-nucleotide polymorphism; Apolipoprotein E; SNP; Alzheimer's disease; Biology; Locus (genetics); Amyloid precursor protein; Disease; Genetics; Internal medicine; Gene; Medicine; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003635672,0.000796632,0.0005068291,0.001217942,0.0005020952,0.0004957793,0.000331922,0.000863814,0.003046272],"category_scores_gemma":[0.001537973,0.0003082952,0.0005355224,0.0007228095,0.00032683,0.0002419157,0.0002967451,0.0004735096,0.0003544742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00012469,"about_ca_system_score_gemma":0.000130084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002312531,"about_ca_topic_score_gemma":0.001431275,"domain_scores_codex":[0.9997069,0.00006421265,0.00005518915,0.00008316046,0.00004706638,0.00004337418],"domain_scores_gemma":[0.9991923,0.000252339,0.0003109782,0.00005792937,0.00007035251,0.0001160658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003826401,0.0003028514,0.9414096,0.00007139674,0.0006405559,0.008416934,0.0006091493,0.0001997492,0.03811301,0.0003151061,0.0003106982,0.00578446],"study_design_scores_gemma":[0.00005482392,0.0004408611,0.9872685,0.00002235148,0.0003358036,0.007820937,0.0002201828,0.0005449419,0.0022587,0.0004596413,0.0005543611,0.00001886788],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992836,0.0001765251,0.0001522101,0.00003743812,0.00001133363,0.000005060387,0.00007080461,0.000006016854,0.0002571006],"genre_scores_gemma":[0.9990224,0.00007890791,0.0002020135,0.00002772063,0.00001713584,0.000006261127,0.0001077065,0.000005640748,0.0005322004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003046272,"threshold_uncertainty_score":0.01019078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02158181215893163,"score_gpt":0.2859223618737809,"score_spread":0.2643405497148493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}