{"id":"W2955019775","doi":"10.3390/cancers11070916","title":"Exploiting Mitochondrial Vulnerabilities to Trigger Apoptosis Selectively in Cancer Cells","year":2019,"lang":"en","type":"review","venue":"Cancers","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"Natural Sciences and Engineering Research Council of Canada; Lotte and John Hecht Memorial Foundation","keywords":"Cancer cell; Oxidative stress; Mitochondrion; DNA damage; Apoptosis; Cell biology; Biology; Programmed cell death; Cancer research; Reactive oxygen species; Mitochondrial ROS; Cancer; Chemistry; Biochemistry; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001659195,0.0005706039,0.001485464,0.0002322541,0.00007070151,0.00005026849,0.0004364313,0.0005162011,0.00009843305],"category_scores_gemma":[0.0001055946,0.0005453053,0.0005391769,0.0004331648,0.00007206004,0.000007576436,0.0001428137,0.0003822347,0.00004371408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001306844,"about_ca_system_score_gemma":0.004038175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008490981,"about_ca_topic_score_gemma":0.0006218083,"domain_scores_codex":[0.9972661,0.0001921299,0.0005904307,0.00103477,0.0002184748,0.0006980597],"domain_scores_gemma":[0.9988342,0.00005029515,0.0002577504,0.0005432322,0.0001182074,0.0001963415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009848105,0.00002428722,0.000003801063,0.005515375,0.0003334137,6.830264e-7,0.000290859,0.0004254249,0.01452174,0.00001847106,0.03781335,0.9409541],"study_design_scores_gemma":[0.0004823465,0.00009253543,7.585525e-7,0.001813212,0.0002364463,0.00000205245,0.00009669382,0.000001576736,0.006146719,0.000003103728,0.990467,0.0006575689],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001084541,0.9878693,0.00006054637,0.00001994164,0.008516364,0.001404147,0.0003366103,0.00001809997,0.0006904594],"genre_scores_gemma":[0.00006463877,0.9866874,0.0001688216,0.0002395886,0.006790408,0.001659745,0.000109006,0.0001238218,0.004156624],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9526536,"threshold_uncertainty_score":0.9996998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04060640768797833,"score_gpt":0.326186892838892,"score_spread":0.2855804851509136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}