{"id":"W2955019775","doi":"10.3390/cancers11070916","title":"Exploiting Mitochondrial Vulnerabilities to Trigger Apoptosis Selectively in Cancer Cells","year":2019,"lang":"en","type":"review","venue":"Cancers","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"Natural Sciences and Engineering Research Council of Canada; Lotte and John Hecht Memorial Foundation","keywords":"Cancer cell; Oxidative stress; Mitochondrion; DNA damage; Apoptosis; Cell biology; Biology; Programmed cell death; Cancer research; Reactive oxygen species; Mitochondrial ROS; Cancer; Chemistry; Biochemistry; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009327011,0.0002576792,0.0001826903,0.0001769917,0.000152889,0.0002025431,0.0001531283,0.0003181066,0.0004965054],"category_scores_gemma":[0.00007121662,0.00007518666,0.0001911719,0.0001334467,0.000147551,0.000245516,0.0002096357,0.0004158742,0.0001410342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002587805,"about_ca_system_score_gemma":0.0001276137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002144695,"about_ca_topic_score_gemma":0.000562333,"domain_scores_codex":[0.9999378,0.00001197501,0.000003925543,0.00001267437,0.00001770477,0.00001593187],"domain_scores_gemma":[0.9999695,0.000005874534,0.000009720948,0.000003526131,0.00000519417,0.000006063741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007961764,0.00004905227,0.0001250179,0.0001857495,0.00001154323,0.000139995,0.00002773383,0.0002207195,0.9906197,0.0008793795,0.0002439385,0.007417586],"study_design_scores_gemma":[0.00002525339,0.000568923,0.0009461842,0.00001098942,0.00002202833,0.0005426035,0.00002062413,0.0006245497,0.9846312,0.0002519771,0.01234963,0.000005991602],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.8926222,0.06737928,0.02662076,0.001316547,0.0003052279,0.0002324045,0.0003221658,0.0004124961,0.01078905],"genre_scores_gemma":[0.9708933,0.02009488,0.0056662,0.0003160458,0.00006383871,0.00007622357,0.0001418207,0.00002087472,0.002726771],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.0004965054,"threshold_uncertainty_score":0.001877546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04060640768797833,"score_gpt":0.326186892838892,"score_spread":0.2855804851509136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}