{"id":"W2955028827","doi":"10.1021/jacs.9b05362","title":"Integrating Activity with Accessibility in Olefin Metathesis: An Unprecedentedly Reactive Ruthenium-Indenylidene Catalyst","year":2019,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Ruthenium; Catalysis; Carbene; Lability; Steric effects; Ligand (biochemistry); Metathesis; Reactivity (psychology); Medicinal chemistry; Olefin metathesis; Olefin fiber; Salt metathesis reaction; Combinatorial chemistry; Stereochemistry; Organic chemistry; Polymerization","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002698059,0.000417174,0.0003011008,0.0002447879,0.0001243605,0.0005420475,0.0004400971,0.0003841179,0.0009803496],"category_scores_gemma":[0.0003458661,0.0002072941,0.0001934604,0.0001981765,0.0002184955,0.0004172402,0.0004609647,0.0006817277,0.0005861176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004252969,"about_ca_system_score_gemma":0.0001701196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003714616,"about_ca_topic_score_gemma":0.0006039088,"domain_scores_codex":[0.9997453,0.00003095515,0.00002026296,0.00006440291,0.00005904231,0.00008008012],"domain_scores_gemma":[0.9998724,0.00002960833,0.00003166556,0.0000278688,0.00001455493,0.00002377325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009728647,0.00005388397,0.0002480698,0.00004791863,0.000008579636,0.00009778625,0.00004471647,0.0003898851,0.9917408,0.0007880318,0.00007237306,0.006410525],"study_design_scores_gemma":[0.0000120867,0.0002002929,0.0003478882,0.000002580137,0.00001133025,0.00008726164,0.000006323859,0.00119042,0.9966241,0.00006726044,0.001443262,0.000007263552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842497,0.001082889,0.00864699,0.0001239954,0.00002220676,0.00004992821,0.000118477,0.0003753683,0.005330467],"genre_scores_gemma":[0.997015,0.0002512164,0.001693974,0.00001026961,0.000005266723,0.00001220743,0.00005733653,0.00003308584,0.0009216655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009803496,"threshold_uncertainty_score":0.003279567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01321139890005629,"score_gpt":0.2908080993652046,"score_spread":0.2775967004651483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}