{"id":"W2955033126","doi":"10.1158/1538-7445.am2019-ct014","title":"Abstract CT014: Initial results from the Phase I study of MSC-1, a humanized anti-LIF monoclonal antibody, in patients with advanced solid tumors","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Interface Biologics (Canada); University of Toronto","funders":"","keywords":"Medicine; Tumor microenvironment; Cancer; Monoclonal antibody; Immunosuppression; Metastasis; Cytokine release syndrome; Cancer research; Cytokine; Antibody; Oncology; Immunotherapy; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005299367,0.000146756,0.000407956,0.0002106269,0.0001070406,0.00002965163,0.0002213515,0.00004571049,0.000657561],"category_scores_gemma":[0.0002116538,0.00009436229,0.00005281194,0.0004463755,0.0001146149,0.000136667,0.00008719126,0.0007606388,0.00003339053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000135627,"about_ca_system_score_gemma":0.0003851547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004937308,"about_ca_topic_score_gemma":0.0004845282,"domain_scores_codex":[0.9976967,0.0001251899,0.0004961761,0.0004131374,0.0009030194,0.0003657745],"domain_scores_gemma":[0.9982733,0.0003873507,0.0001484536,0.000515193,0.0005825369,0.00009318427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0454277,0.01036823,0.3876275,0.0001018894,0.0003798668,0.0001380918,0.008850133,0.0005504691,0.5383406,0.00001698818,0.001014961,0.007183597],"study_design_scores_gemma":[0.049158,0.0058078,0.8991025,0.00106028,0.00003318828,0.000001391454,0.003050773,0.0001504501,0.04096807,0.00001298573,0.0004841986,0.0001703543],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969311,0.00005741726,0.000001388724,0.0001826678,0.0001400245,0.00166169,0.000367713,0.00001581788,0.0006421676],"genre_scores_gemma":[0.9993961,0.00001946141,0.00002009578,0.00004197597,0.000162854,0.00006929224,0.0001978845,0.000030053,0.00006230638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.511475,"threshold_uncertainty_score":0.7463766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08070228339118513,"score_gpt":0.4629608044383988,"score_spread":0.3822585210472137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}