{"id":"W2955033126","doi":"10.1158/1538-7445.am2019-ct014","title":"Abstract CT014: Initial results from the Phase I study of MSC-1, a humanized anti-LIF monoclonal antibody, in patients with advanced solid tumors","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Interface Biologics (Canada); University of Toronto","funders":"","keywords":"Medicine; Tumor microenvironment; Cancer; Monoclonal antibody; Immunosuppression; Metastasis; Cytokine release syndrome; Cancer research; Cytokine; Antibody; Oncology; Immunotherapy; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001402213,0.001521751,0.001514101,0.0004551334,0.0004464939,0.000885907,0.0007391182,0.001142332,0.003307074],"category_scores_gemma":[0.0009366169,0.0003183629,0.0008508647,0.0003958221,0.0007735043,0.0005469637,0.0003382958,0.002978018,0.001070887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009300138,"about_ca_system_score_gemma":0.001517098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00128062,"about_ca_topic_score_gemma":0.00241586,"domain_scores_codex":[0.9996191,0.000171668,0.0000226409,0.00005365961,0.0000573034,0.00007552747],"domain_scores_gemma":[0.9992591,0.0001749971,0.00008188743,0.00004689162,0.00006310101,0.0003740799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2966297,0.09411035,0.0294995,0.001347797,0.001393781,0.001334229,0.0007640487,0.007755606,0.3136746,0.0008465882,0.01751844,0.2351254],"study_design_scores_gemma":[0.1503485,0.7621413,0.03592739,0.00009258338,0.0006868003,0.001239131,0.00008482116,0.002456805,0.03801516,0.0003373128,0.00862645,0.00004355407],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851312,0.003233723,0.001399807,0.0009564431,0.00008493639,0.00196602,0.002769825,0.0001860687,0.004272013],"genre_scores_gemma":[0.9795313,0.00185139,0.003031782,0.001069202,0.0001820496,0.001959817,0.008713193,0.00006155172,0.003599758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003307074,"threshold_uncertainty_score":0.01106328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08070228339118513,"score_gpt":0.4629608044383988,"score_spread":0.3822585210472137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}