{"id":"W2955039931","doi":"10.1038/s41586-019-1318-9","title":"FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes","year":2019,"lang":"en","type":"article","venue":"Nature","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":284,"is_retracted":false,"has_abstract":false,"ca_institutions":"Genome British Columbia","funders":"National Institute of General Medical Sciences; National Cancer Institute; Howard Hughes Medical Institute","keywords":"Prostate cancer; Phenotype; Biology; FOXA1; Cancer; Cancer research; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002287873,0.00006977694,0.00005070214,0.00002519433,0.00003189672,0.00002086361,0.00003127852,0.0002926226,0.00003340474],"category_scores_gemma":[0.000006878644,0.00006503586,0.00002253184,0.00003742669,0.00001249918,0.000009611043,0.00001556863,0.0001990143,0.000004970865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001016641,"about_ca_system_score_gemma":0.00001259528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009270091,"about_ca_topic_score_gemma":0.00004070802,"domain_scores_codex":[0.999617,0.0000130876,0.00005049968,0.000164294,0.00007568545,0.00007944357],"domain_scores_gemma":[0.9998081,0.000003172651,0.00002993105,0.0000934143,0.00004226185,0.00002312526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00002970027,0.00001117698,0.01950277,0.00002319602,0.00001994784,7.228042e-8,0.00007394508,0.000212809,0.9771411,0.0000856105,0.000129432,0.002770215],"study_design_scores_gemma":[0.0005482398,0.00005606017,0.573479,0.00001835902,0.00001915907,0.00000184594,0.0000168557,0.000795332,0.4180297,0.000112053,0.006768275,0.0001550736],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981176,0.0006522781,0.0003009824,0.0003476908,0.0002465847,0.00016867,0.00002350431,0.00001318762,0.0001294991],"genre_scores_gemma":[0.998718,0.00006455473,0.00009072202,0.0001029441,0.00006745128,0.0000127563,0.0001337428,0.00001113777,0.0007987292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5591114,"threshold_uncertainty_score":0.2652085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004184295090030691,"score_gpt":0.2411702099628923,"score_spread":0.2369859148728616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}