{"id":"W2955084511","doi":"10.1158/1055-9965.epi-18-0915","title":"Effects of Switching to a Heat-Not-Burn Tobacco Product on Biologically Relevant Biomarkers to Assess a Candidate Modified Risk Tobacco Product: A Randomized Trial","year":2019,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Smoking Behavior and Cessation","field":"Medicine","cited_by":135,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"U.S. Food and Drug Administration; American Association for Cancer Research","keywords":"Medicine; Tobacco product; Nicotine; Randomized controlled trial; Smoke; Tobacco harm reduction; Regimen; Cotinine; Tobacco smoke; Internal medicine; Tobacco use; Environmental health; Chemistry; Population","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.009991158,0.0005589687,0.002361857,0.0006150539,0.0001410036,0.00001993803,0.0003075972,0.0003789933,0.0000889166],"category_scores_gemma":[0.01083532,0.0004172668,0.0007095265,0.0007496295,0.0001454794,0.000140271,0.0001249936,0.0004674602,0.00002666017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005560242,"about_ca_system_score_gemma":0.0003471259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0021772,"about_ca_topic_score_gemma":0.0001003695,"domain_scores_codex":[0.9920316,0.003444715,0.0017289,0.001581022,0.0004113199,0.0008024612],"domain_scores_gemma":[0.9949822,0.00250112,0.0008956863,0.0009652138,0.0002932708,0.0003625484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6786928,0.000516114,0.162294,0.0002559156,0.001467789,0.00001016724,0.0002396731,0.000224804,0.1041262,0.0001037033,0.001617907,0.05045092],"study_design_scores_gemma":[0.4350339,0.004413408,0.5064449,0.002895142,0.002445669,0.00001906159,0.00008885253,0.0002694201,0.04610246,0.0009002885,0.0004922213,0.0008946457],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9740235,0.0007863142,0.003439812,0.005409297,0.003008172,0.01305064,0.00002791604,0.0001482362,0.0001060838],"genre_scores_gemma":[0.993278,0.0004277067,0.001893456,0.001211214,0.0004321256,0.002317216,0.0001285077,0.0000565523,0.0002552105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3441509,"threshold_uncertainty_score":0.9998279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05253109568022572,"score_gpt":0.3720196807834964,"score_spread":0.3194885851032707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}