{"id":"W2955134213","doi":"10.1073/pnas.1900576116","title":"Axonal pathology in hPSC-based models of Parkinson’s disease results from loss of Nrf2 transcriptional activity at the Map1b gene locus","year":2019,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Parkinson Society Canada; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Neuropathology; Biology; Parkinson's disease; Neuroscience; Cell biology; Stem cell; Locus coeruleus; Microtubule; Disease; Pathology; Central nervous system; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002254989,0.0002759597,0.000221893,0.000530878,0.0002881877,0.0002644254,0.000182065,0.0003328999,0.002224883],"category_scores_gemma":[0.00006034632,0.0001075579,0.0002444588,0.0001775114,0.0003470347,0.0002192938,0.0001760282,0.0008725163,0.0004555134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000276429,"about_ca_system_score_gemma":0.0001709562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001048841,"about_ca_topic_score_gemma":0.002085282,"domain_scores_codex":[0.9998751,0.00001658673,0.00001454431,0.00002895634,0.00004749349,0.00001739249],"domain_scores_gemma":[0.9999005,0.00001052752,0.00002032343,0.00001614784,0.0000123267,0.00004022807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001595817,0.0001313829,0.0002368945,0.00004807803,0.00001216676,0.0001001124,0.00003759846,0.0000814602,0.9973902,0.0002246162,0.0001117061,0.001466324],"study_design_scores_gemma":[0.00003274848,0.0006112339,0.003409892,0.00001380229,0.00002740212,0.0002906759,0.000042739,0.0008127475,0.9920887,0.0001236201,0.00254248,0.000003831492],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903066,0.0008565211,0.003947697,0.0002405377,0.00007703796,0.00005680385,0.0008233749,0.0001704345,0.003520918],"genre_scores_gemma":[0.9846742,0.0009555578,0.003202733,0.00008541007,0.00001228901,0.00009937967,0.001014547,0.00003903018,0.009916812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002224883,"threshold_uncertainty_score":0.007443011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04642736513356917,"score_gpt":0.2896333891491173,"score_spread":0.2432060240155482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}