{"id":"W2955142030","doi":"10.1158/1538-7445.am2019-lb-288","title":"Abstract LB-288: CDC7 kinase inhibition by SRA141 induces a potentially novel caspase-dependent tumor cell apoptosis associated with altered DNA replication and cell cycle dynamics","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Precision Nanosystems (Canada)","funders":"","keywords":"Control of chromosome duplication; DNA replication; S phase; DNA re-replication; Eukaryotic DNA replication; Biology; Minichromosome maintenance; Pre-replication complex; Origin recognition complex; DNA replication factor CDT1; Cell cycle; Replication factor C; Cell biology; Mitosis; DNA; Cancer research; Apoptosis; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001362409,0.0003944724,0.0004556946,0.0002334437,0.0001426995,0.0002214121,0.0002690989,0.0002902652,0.001518223],"category_scores_gemma":[0.00007464957,0.000116856,0.0003196659,0.0001810521,0.0001669156,0.000127883,0.0001387196,0.0006717271,0.0004761074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002281592,"about_ca_system_score_gemma":0.000243411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002691382,"about_ca_topic_score_gemma":0.0004321766,"domain_scores_codex":[0.9998668,0.00001955296,0.0000194257,0.00002425009,0.00003665054,0.00003328951],"domain_scores_gemma":[0.9999189,0.0000131072,0.00002014162,0.00001328918,0.00001231676,0.00002229223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002486102,0.0001006016,0.0001244798,0.0000465775,0.000008855778,0.00006116149,0.00000687049,0.00005742878,0.9979147,0.00006172937,0.00004875028,0.001320167],"study_design_scores_gemma":[0.00003688964,0.0007237711,0.001675888,0.000002872183,0.000009747302,0.0001818305,0.000009722376,0.0007180031,0.9956806,0.00001941296,0.0009387801,0.00000258502],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953194,0.00147413,0.001452274,0.00008574249,0.00003466194,0.00004873287,0.0004206109,0.00009612287,0.001068167],"genre_scores_gemma":[0.9942888,0.0006781051,0.001732064,0.00003733671,0.00001036856,0.00006614464,0.0008388078,0.00001413457,0.002334354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001518223,"threshold_uncertainty_score":0.005078971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01533969940849665,"score_gpt":0.2842358806399598,"score_spread":0.2688961812314631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}