{"id":"W2955224514","doi":"10.1080/24745332.2019.1624227","title":"VX-659–Tezacaftor–Ivacaftor in patients with cystic fibrosis and one or two Phe508del alleles","year":2019,"lang":"en","type":"article","venue":"Canadian Journal of Respiratory Critical Care and Sleep Medicine","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Toronto Western Hospital; University of Toronto","funders":"","keywords":"Ivacaftor; Cystic fibrosis; Allele; Medicine; Genetics; Biology; Internal medicine; Cystic fibrosis transmembrane conductance regulator","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001945418,0.0002117743,0.0003834899,0.0002349677,0.0003291178,0.0002535443,0.0001815766,0.0006084284,0.001977108],"category_scores_gemma":[0.0004883603,0.00006580821,0.0003522965,0.0002608651,0.0002328797,0.0002971474,0.0001505434,0.000660801,0.000298287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004035927,"about_ca_system_score_gemma":0.000605436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003179813,"about_ca_topic_score_gemma":0.007551839,"domain_scores_codex":[0.9998671,0.00002548393,0.00001408176,0.00002371192,0.00002776236,0.0000418374],"domain_scores_gemma":[0.9998536,0.0000264865,0.00002875867,0.000005406306,0.000008899824,0.00007680133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02243366,0.00175519,0.7369865,0.0002665404,0.0004343725,0.03633166,0.0003085119,0.000644404,0.02195075,0.001116022,0.01420026,0.1635721],"study_design_scores_gemma":[0.003013009,0.01390931,0.8946018,0.0004144612,0.0004812132,0.05902709,0.0004554695,0.001443916,0.003851127,0.001245926,0.02149048,0.00006612699],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9763533,0.007334768,0.0002875694,0.00295578,0.0002989613,0.00007115378,0.0003770131,0.00005372506,0.01226766],"genre_scores_gemma":[0.995804,0.00123989,0.0002616468,0.0009112611,0.0001183458,0.0000166367,0.0003438412,0.000004986969,0.00129936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003179813,"threshold_uncertainty_score":0.006614089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01799570679810864,"score_gpt":0.2992857102362589,"score_spread":0.2812900034381502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}