{"id":"W2955227933","doi":"10.1158/1538-7445.am2019-3123","title":"Abstract 3123: Targeting SHP2 and RAS MAPK pathway in neuroblastoma","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Neuroblastoma RAS viral oncogene homolog; Cancer research; MAPK/ERK pathway; Neuroblastoma; PTPN11; Biology; Signal transduction; Protein tyrosine phosphatase; Effector; Cell growth; Apoptosis; Cell culture; Mutation; Immunology; Cell biology; Genetics; KRAS; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007699833,0.0001124374,0.0001294804,0.0001254995,0.00008159241,0.00005424712,0.0002373515,0.0001222995,0.0003768721],"category_scores_gemma":[0.0001650519,0.0001042025,0.00003787643,0.0002131807,0.0001287651,0.000008073631,0.0003155261,0.0004133972,0.0001049616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003688382,"about_ca_system_score_gemma":0.0002431063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003380955,"about_ca_topic_score_gemma":0.0001466896,"domain_scores_codex":[0.9982845,0.0001266233,0.0001610048,0.0004772581,0.0003573142,0.0005932605],"domain_scores_gemma":[0.999362,0.00007192558,0.00002313606,0.000289608,0.0001156367,0.0001377136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001392713,0.00003215784,0.01155984,0.00007460855,0.00001015758,0.00003056975,0.00003907261,0.00002949411,0.9800125,0.00003087689,0.002113462,0.005928037],"study_design_scores_gemma":[0.0007791232,0.000263804,0.02122901,0.00008238744,7.921796e-7,0.000002536247,0.0002593133,0.00007364383,0.9078549,0.00006143612,0.06919146,0.0002016254],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945046,0.002192981,0.000004957099,0.0003145284,0.00007305638,0.0003098558,0.00002005961,0.000006884046,0.002573043],"genre_scores_gemma":[0.9969805,0.000910194,0.00002672174,0.00007338629,0.0002175172,0.00006781596,0.00002443875,0.00002961083,0.00166978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07215758,"threshold_uncertainty_score":0.4249256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03312804763409139,"score_gpt":0.3684175530705048,"score_spread":0.3352895054364134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}