{"id":"W2955227933","doi":"10.1158/1538-7445.am2019-3123","title":"Abstract 3123: Targeting SHP2 and RAS MAPK pathway in neuroblastoma","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Neuroblastoma RAS viral oncogene homolog; Cancer research; MAPK/ERK pathway; Neuroblastoma; PTPN11; Biology; Signal transduction; Protein tyrosine phosphatase; Effector; Cell growth; Apoptosis; Cell culture; Mutation; Immunology; Cell biology; Genetics; KRAS; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001589242,0.000474688,0.0004150874,0.0001950159,0.0001941056,0.0002487501,0.0002902555,0.0002952956,0.002040231],"category_scores_gemma":[0.00006836736,0.0001178338,0.0002496144,0.0002025734,0.0001671396,0.0001608386,0.0002101043,0.0007305232,0.000676721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004294706,"about_ca_system_score_gemma":0.0004644367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001557217,"about_ca_topic_score_gemma":0.003268005,"domain_scores_codex":[0.9998727,0.00001392789,0.00001496012,0.00002105908,0.00004960762,0.00002766523],"domain_scores_gemma":[0.9999652,0.000004763024,0.000006964585,0.000003695369,0.000005857094,0.00001364074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004484596,0.0001677874,0.0004406297,0.0001540309,0.00002092852,0.000121303,0.00001387869,0.0002260401,0.9927871,0.00008922577,0.0004614412,0.005069284],"study_design_scores_gemma":[0.0001466741,0.001800091,0.005745749,0.00001854848,0.00004789235,0.0006393312,0.00003008108,0.001021311,0.98259,0.0000451024,0.007907342,0.0000078083],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9853289,0.004494397,0.001857007,0.0003264699,0.0001304991,0.0001917013,0.002167307,0.0001467707,0.00535696],"genre_scores_gemma":[0.9825982,0.004378136,0.00315082,0.0001761438,0.00002708101,0.0002001993,0.003276972,0.00002154064,0.006170853],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.002040231,"threshold_uncertainty_score":0.006825268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03312804763409139,"score_gpt":0.3684175530705048,"score_spread":0.3352895054364134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}