{"id":"W2955262879","doi":"10.1002/mus.26617","title":"Amyotrophic lateral sclerosis: Origins traced to impaired balance between neural excitation and inhibition in the neonatal period","year":2019,"lang":"en","type":"review","venue":"Muscle & Nerve","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Amyotrophic lateral sclerosis; Neuroscience; Excitotoxicity; Neurodegeneration; Inhibitory postsynaptic potential; Medicine; Disease; Prodrome; Excitatory postsynaptic potential; Psychology; Pathology; Glutamate receptor; Internal medicine; Psychiatry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006622283,0.0005696547,0.001648303,0.0004128725,0.0001361511,0.000212535,0.0002763484,0.0004178885,0.00006594659],"category_scores_gemma":[0.0001198751,0.0003768216,0.0003814397,0.0009424809,0.0001042463,0.0002895372,0.0001687082,0.001121726,0.0001586708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000599281,"about_ca_system_score_gemma":0.0002334481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003648689,"about_ca_topic_score_gemma":0.00004708197,"domain_scores_codex":[0.9961566,0.0006113448,0.0008444884,0.0008370422,0.000801978,0.0007485035],"domain_scores_gemma":[0.9985198,0.0002014633,0.0002237206,0.0006689869,0.0001126654,0.0002733213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0001012073,0.0001013301,0.001162219,0.008044667,0.0001045513,0.000287529,0.002207907,0.000006148185,0.0004014242,0.00006037514,0.0003185182,0.9872041],"study_design_scores_gemma":[0.003544289,0.001522344,0.7823829,0.0234816,0.0007988601,0.0002497935,0.0001347193,0.000346555,0.000003847127,0.00004773072,0.1864516,0.001035727],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6052809,0.3899386,0.000008409491,0.001560844,0.0001315298,0.002868896,0.0001235676,0.00006018981,0.00002698098],"genre_scores_gemma":[0.5838107,0.4139551,0.00008991724,0.0002555416,0.0006357803,0.0004443023,0.0005767856,0.0001030131,0.0001289075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9861684,"threshold_uncertainty_score":0.9998684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.107513182659815,"score_gpt":0.3497580072672617,"score_spread":0.2422448246074467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}