{"id":"W2955273706","doi":"10.1186/s13195-019-0511-2","title":"An experimental model of Braak’s pretangle proposal for the origin of Alzheimer’s disease: the role of locus coeruleus in early symptom development","year":2019,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Institute of Neurosciences, Mental Health and Addiction; Canadian Institutes of Health Research; Strong","keywords":"Locus coeruleus; Tauopathy; Neuroscience; Serotonergic; Psychology; Alzheimer's disease; Cerebral cortex; Medicine; Disease; Neurodegeneration; Pathology; Internal medicine; Central nervous system; Serotonin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000379976,0.001151989,0.0006014239,0.001017066,0.0006492554,0.0004999411,0.001150511,0.001034148,0.003031191],"category_scores_gemma":[0.0002534329,0.0003111232,0.0005792947,0.0003227265,0.00108641,0.0007796751,0.0005388311,0.00213896,0.0007489282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00088151,"about_ca_system_score_gemma":0.0008769993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00160402,"about_ca_topic_score_gemma":0.002977643,"domain_scores_codex":[0.9995925,0.00003249927,0.00003875643,0.0001374192,0.00009950241,0.00009934141],"domain_scores_gemma":[0.9992834,0.00007813347,0.000168256,0.00015947,0.00008282017,0.0002280804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002091641,0.002966908,0.001187353,0.0001212812,0.00003193444,0.000886357,0.0001557769,0.000142732,0.9861186,0.0009728037,0.0003268347,0.004997702],"study_design_scores_gemma":[0.0008628779,0.03120129,0.02059003,0.0001492354,0.0001735535,0.004600412,0.0003909874,0.00257455,0.9280671,0.001204991,0.01009674,0.00008818367],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911487,0.0008148103,0.004016181,0.0003614877,0.0002019846,0.0004523513,0.0006029465,0.0002165681,0.002184877],"genre_scores_gemma":[0.9725375,0.001374976,0.01047793,0.0003912502,0.00007221662,0.0009767594,0.001116161,0.00007403558,0.01297924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003031191,"threshold_uncertainty_score":0.01014036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08251033662228607,"score_gpt":0.392265910970526,"score_spread":0.30975557434824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}