{"id":"W2955350141","doi":"10.1158/1538-7445.am2019-1292","title":"Abstract 1292: A new generation of N-terminal domain androgen receptor inhibitors, with improved pharmaceutical properties, in castration-resistant prostate cancer models","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Androgen receptor; Prostate cancer; ADME; In vivo; Androgen; Potency; Chemistry; Pharmacology; Dihydrotestosterone; Cancer research; Cancer; In vitro; Pharmacokinetics; Biology; Medicine; Internal medicine; Biochemistry; Hormone; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002544571,0.0004673024,0.0003071855,0.0002524273,0.0001061246,0.000349586,0.0003089834,0.000291023,0.002105606],"category_scores_gemma":[0.00007216028,0.0001310363,0.000265969,0.0001779524,0.0001290476,0.0002662323,0.0001171777,0.001017438,0.0007079506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003319811,"about_ca_system_score_gemma":0.0004172617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001326295,"about_ca_topic_score_gemma":0.002353424,"domain_scores_codex":[0.9998986,0.00001432451,0.000005959365,0.00001414886,0.00004892855,0.00001818319],"domain_scores_gemma":[0.9999512,0.000004412744,0.000009638446,0.000005009372,0.00001241068,0.00001724104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005724844,0.0003675671,0.0001261329,0.0001336867,0.00001902475,0.00006424463,0.00001425002,0.0005817687,0.9846163,0.0006343947,0.001612519,0.01125764],"study_design_scores_gemma":[0.0003030181,0.004245527,0.00179792,0.00001414593,0.00006415617,0.0003567279,0.00001493943,0.004124397,0.9655926,0.0001421789,0.02332602,0.00001843463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9445564,0.009647368,0.02037359,0.0007082753,0.0003053691,0.0003772453,0.004561842,0.00113772,0.01833211],"genre_scores_gemma":[0.9457317,0.006369963,0.01202996,0.0002708002,0.00005183041,0.0002443235,0.005340105,0.0001187962,0.02984253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002105606,"threshold_uncertainty_score":0.007043898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1406769707080023,"score_gpt":0.404920585455404,"score_spread":0.2642436147474017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}