{"id":"W2955366227","doi":"10.1126/science.aaw4144","title":"The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling","year":2019,"lang":"en","type":"article","venue":"Science","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; Massachusetts Institute of Technology; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Innate immune system; Cytosol; Heme; Cell biology; Chemistry; Immune system; Signal transduction; Biology; Biochemistry; Immunology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001257605,0.0003184109,0.0002545388,0.0001858129,0.0001888846,0.00034657,0.0001513786,0.0002155041,0.0007340824],"category_scores_gemma":[0.00006421818,0.00009997349,0.0001477432,0.000109819,0.0001895823,0.0002442829,0.0002149259,0.0002691916,0.0002946865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004539436,"about_ca_system_score_gemma":0.0001431085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002747966,"about_ca_topic_score_gemma":0.0003133071,"domain_scores_codex":[0.9998989,0.00001321682,0.000005731548,0.00003002455,0.00002605035,0.00002598991],"domain_scores_gemma":[0.999933,0.00000419898,0.00002301708,0.000006189271,0.000008725807,0.0000249548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008246636,0.000006106755,0.0002251332,0.00002110999,0.000002993256,0.00005104947,0.000003639915,0.00004033385,0.9984543,0.0001752865,0.00004299571,0.0008945848],"study_design_scores_gemma":[0.00001281784,0.0001490792,0.01270255,0.000006269193,0.00001035537,0.0006485083,0.00002460511,0.002278409,0.980451,0.0002084652,0.003499768,0.000008140926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.973729,0.005458244,0.01618824,0.0002703874,0.00007158371,0.00003899756,0.0005343,0.0003887,0.003320534],"genre_scores_gemma":[0.9943362,0.0004543964,0.002893106,0.00003562724,0.00001119112,0.000008200159,0.0003228643,0.00001475913,0.001923649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007340824,"threshold_uncertainty_score":0.003293633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0082306705922322,"score_gpt":0.2408772549446776,"score_spread":0.2326465843524454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}