{"id":"W2955389905","doi":"10.1158/1078-0432.ccr-19-0823","title":"Mechanisms of Innate and Acquired Resistance to Anti-EGFR Therapy: A Review of Current Knowledge with a Focus on Rechallenge Therapies","year":2019,"lang":"en","type":"review","venue":"Clinical Cancer Research","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC","funders":"National Center for Advancing Translational Sciences; National Cancer Institute","keywords":"Ectodomain; PTEN; Medicine; Acquired resistance; Cancer; Cancer research; PI3K/AKT/mTOR pathway; Signal transduction; Biology; Internal medicine; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002696593,0.0004432988,0.004335315,0.0003030524,0.00007878877,0.00001107096,0.0003263669,0.0002219841,0.000123135],"category_scores_gemma":[0.0004312687,0.0002467423,0.0004923476,0.000950964,0.0004542508,0.00002738829,0.000260298,0.0007411603,0.00001758382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002888251,"about_ca_system_score_gemma":0.00142634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003552308,"about_ca_topic_score_gemma":0.0001619702,"domain_scores_codex":[0.9956118,0.0009282212,0.001252516,0.0008896825,0.0008676903,0.0004500999],"domain_scores_gemma":[0.9959192,0.001531056,0.0004636026,0.0008633153,0.001000928,0.0002218689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001837676,0.0005568617,0.00002086374,0.1313932,0.0008899477,0.000009461988,0.0001762231,4.461962e-9,0.000001270382,0.0004115255,0.001907329,0.8627957],"study_design_scores_gemma":[0.001208472,0.004843957,0.0001991697,0.2999151,0.0004310178,0.000001976865,0.00002690402,6.960444e-8,0.00001324843,0.0001665597,0.69302,0.0001734909],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001560783,0.9911398,0.0000038769,0.001297633,0.0002127652,0.004681439,0.0001566467,0.00001625673,0.002335487],"genre_scores_gemma":[0.001044887,0.9968215,0.00006875957,0.00009115453,0.000129349,0.001049484,0.00001169468,0.00007592737,0.0007072144],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8626221,"threshold_uncertainty_score":0.9999985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5085590877799051,"score_gpt":0.5932886371081418,"score_spread":0.08472954932823673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}