{"id":"W2955435177","doi":"10.1074/jbc.ra119.008291","title":"A positive feedback loop involving nuclear factor IB and calpain 1 suppresses glioblastoma cell migration","year":2019,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Calpain; Calpastatin; Biology; NFAT; Cell biology; Calcineurin; Cytoplasm; Proteases; Transcription factor; Molecular biology; Transplantation; Gene; Biochemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001111925,0.0003801736,0.0002542768,0.000175491,0.0001128814,0.0002206026,0.0002050919,0.0001518315,0.001381169],"category_scores_gemma":[0.0001072293,0.0000990078,0.0002159093,0.00009597703,0.0001882792,0.0001171658,0.0001211539,0.0005224725,0.0001975045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003400166,"about_ca_system_score_gemma":0.0002263202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006844978,"about_ca_topic_score_gemma":0.001663639,"domain_scores_codex":[0.9998728,0.00001609911,0.000009282559,0.00002565438,0.00004334978,0.00003277382],"domain_scores_gemma":[0.9999129,0.00001050947,0.00003273577,0.00001010403,0.000009847733,0.00002390364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004210473,0.0000140337,0.0001109199,0.00001755715,0.000002987995,0.0000258824,0.000004335971,0.00001521812,0.9990081,0.00005084301,0.00002237172,0.0006855406],"study_design_scores_gemma":[0.00001383192,0.0002417,0.002387285,0.000003941241,0.00001835962,0.0002026462,0.00001923887,0.0006047304,0.9947085,0.00005339982,0.001744181,0.000002043467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916186,0.00246239,0.004376747,0.0001489127,0.00008950037,0.0000271179,0.0002409188,0.0002284659,0.000807502],"genre_scores_gemma":[0.9954744,0.0006121885,0.001856546,0.00005181235,0.00001291395,0.00002498269,0.0003248123,0.00002269025,0.001619609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001381169,"threshold_uncertainty_score":0.004620433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00666134607407579,"score_gpt":0.2044997819659684,"score_spread":0.1978384358918926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}