{"id":"W2955435177","doi":"10.1074/jbc.ra119.008291","title":"A positive feedback loop involving nuclear factor IB and calpain 1 suppresses glioblastoma cell migration","year":2019,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Calpain; Calpastatin; Biology; NFAT; Cell biology; Calcineurin; Cytoplasm; Proteases; Transcription factor; Molecular biology; Transplantation; Gene; Biochemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001331291,0.0001275352,0.0001638302,0.00001904875,0.00004542785,0.00003294261,0.00008952641,0.0002679477,0.0002411866],"category_scores_gemma":[0.0001204191,0.00009198851,0.0001099027,0.00004805165,0.00006985354,0.000009091875,0.00006277637,0.0001572507,0.00000655367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001997657,"about_ca_system_score_gemma":0.00003112656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001923433,"about_ca_topic_score_gemma":7.685897e-7,"domain_scores_codex":[0.999267,0.00005391765,0.0002517019,0.0001869701,0.0001098451,0.000130523],"domain_scores_gemma":[0.9993961,0.00003199539,0.0002249222,0.000102665,0.000136882,0.0001074452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003917157,0.00006141197,0.003935409,0.00003751087,0.00002468093,0.000004136695,0.00002737148,0.00001433534,0.9943491,0.000002321401,0.0006637025,0.0004883053],"study_design_scores_gemma":[0.0006929038,0.0006702337,0.007273613,0.00003993957,0.00001176154,0.0001215483,0.0002362363,0.0001627479,0.9843176,0.00002896548,0.006288451,0.000156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985227,0.0007373017,0.0001106447,0.0001836411,0.00008034807,0.00008408111,0.00001320045,0.000006463258,0.0002616416],"genre_scores_gemma":[0.9985704,0.0002458006,0.000188722,0.0001579206,0.000249923,9.539132e-7,0.00002366685,0.000009352924,0.0005532693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0100315,"threshold_uncertainty_score":0.3751182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00666134607407579,"score_gpt":0.2044997819659684,"score_spread":0.1978384358918926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}