{"id":"W2955482511","doi":"10.1016/j.bbi.2019.07.003","title":"Interplay between inflammation and neural plasticity: Both immune activation and suppression impair LTP and BDNF expression","year":2019,"lang":"en","type":"article","venue":"Brain Behavior and Immunity","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":151,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre hospitalier universitaire de Québec","funders":"Ministero della Salute","keywords":"Inflammation; Kynurenine pathway; Kynurenine; Lipopolysaccharide; Long-term potentiation; Neuroplasticity; Microglia; Immune system; Neuroinflammation; Synaptic plasticity; Prostaglandin E2; Endocrinology; Immunology; Internal medicine; Medicine; Chemistry; Pharmacology; Neuroscience; Biology; Tryptophan; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002074916,0.0002996401,0.0004209659,0.0001626168,0.0002329692,0.0004026286,0.0002132447,0.0003563842,0.00139457],"category_scores_gemma":[0.0001716118,0.0001190933,0.0003341301,0.0001147054,0.0004048184,0.0003545014,0.000300943,0.0008414584,0.0001771474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002833158,"about_ca_system_score_gemma":0.000470629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006378663,"about_ca_topic_score_gemma":0.001684961,"domain_scores_codex":[0.999824,0.00003047709,0.00001489586,0.00002679747,0.00003174391,0.00007221722],"domain_scores_gemma":[0.9998795,0.00001350044,0.00003635968,0.0000146868,0.00001475402,0.00004123189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001125895,0.0001115256,0.000811413,0.00008310006,0.00002936138,0.0001206919,0.0000399496,0.00007168874,0.9909562,0.0004825271,0.0001145397,0.006052904],"study_design_scores_gemma":[0.0001016608,0.002490684,0.03386153,0.00005994416,0.0001762991,0.0009788835,0.0003265937,0.001004372,0.9568953,0.001482192,0.002608062,0.00001453449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922862,0.003241652,0.00244828,0.0006250804,0.00006835255,0.00001507785,0.0001073846,0.0000434636,0.001164493],"genre_scores_gemma":[0.9970543,0.001050821,0.0007313746,0.000103757,0.0000189366,0.00001614639,0.0000429793,0.000007470485,0.0009742153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00139457,"threshold_uncertainty_score":0.004665315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01904347968242054,"score_gpt":0.2847482691381847,"score_spread":0.2657047894557641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}