{"id":"W2955588652","doi":"","title":"Synthetic analogs of the marine natural product hemiasterlin: Optimization and discovery of E7974, a novel and potent antitumor agent","year":2005,"lang":"en","type":"article","venue":"Cancer Research","topic":"Marine Sponges and Natural Products","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Chemistry; Stereochemistry; Quantitative structure–activity relationship; Natural product; Topoisomerase; Steric effects; Combinatorial chemistry; DNA; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001701746,0.0002659733,0.0002851792,0.0003378937,0.0001219812,0.000221167,0.000295364,0.0001821002,0.00172718],"category_scores_gemma":[0.0002492375,0.000107946,0.0001784031,0.00029809,0.0001644893,0.0001390505,0.0001853662,0.000345118,0.0003255097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002586675,"about_ca_system_score_gemma":0.0002948121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004774523,"about_ca_topic_score_gemma":0.001606415,"domain_scores_codex":[0.9999056,0.00002414693,0.00001192258,0.00001540375,0.0000281494,0.00001479202],"domain_scores_gemma":[0.999911,0.00001334861,0.00002194992,0.00001026964,0.00001521059,0.00002827288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001177513,0.0005645782,0.001292797,0.0003525117,0.00005816457,0.0006625659,0.00006066818,0.01016485,0.9402891,0.0007602981,0.0005567668,0.04406013],"study_design_scores_gemma":[0.001027485,0.01191456,0.005272117,0.00005010935,0.0001565693,0.00110415,0.000100139,0.006089697,0.9467289,0.000299583,0.02722711,0.00002955146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868237,0.003780905,0.003324327,0.0001634415,0.00004103591,0.0002597797,0.0008723528,0.00005505379,0.004679479],"genre_scores_gemma":[0.9865432,0.002870752,0.007276488,0.00008319837,0.00001879775,0.00009537186,0.001022705,0.0000148988,0.002074688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00172718,"threshold_uncertainty_score":0.005778015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02165241896939461,"score_gpt":0.3138054095067118,"score_spread":0.2921529905373171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}