{"id":"W2955654457","doi":"10.1021/acsmedchemlett.9b00221","title":"<i>In Vitro</i> Assessment of Putative PD-1/PD-L1 Inhibitors: Suggestions of an Alternative Mode of Action","year":2019,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Canadian Cancer Society Research Institute; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Michael Smith Health Research BC; University of Victoria","keywords":"Mode of action; In vitro; Action (physics); Pharmacology; Computational biology; Combinatorial chemistry; Chemistry; Computer science; Medicine; Information retrieval; Biology; Biochemistry; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002300856,0.0001518583,0.0004395205,0.00008575737,0.0000119498,0.000001996165,0.0001131351,0.00008382049,0.00008722774],"category_scores_gemma":[0.00002789215,0.0001353582,0.00009933822,0.0002315125,0.0002489085,0.0001276558,0.00001955133,0.0002486856,5.357782e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002001365,"about_ca_system_score_gemma":0.0001567892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007736515,"about_ca_topic_score_gemma":0.000003197082,"domain_scores_codex":[0.998584,0.00004054969,0.0004956533,0.0002314226,0.0004846432,0.0001637428],"domain_scores_gemma":[0.9990536,0.0001051207,0.0003931323,0.000264926,0.0001172294,0.00006596502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001867127,0.0002123493,0.001523478,0.0005209588,0.0001552328,0.0000150116,0.0008856725,0.0001274827,0.9935514,0.000003043466,0.0001510576,0.0009871478],"study_design_scores_gemma":[0.00311896,0.0002556571,0.004299974,0.0004310443,0.00008456577,0.00002987563,0.001319507,0.0003342798,0.9899245,0.00002193796,0.00007923219,0.0001004865],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996457,0.00006501009,0.0001597279,0.002218876,0.0001649339,0.0002522807,0.00005548172,0.000008504535,0.0006182158],"genre_scores_gemma":[0.9984779,0.00004594752,0.0006132424,0.0005203746,0.0001416673,0.00001365542,0.0001070878,0.00001465279,0.00006544841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003626959,"threshold_uncertainty_score":0.5519745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01236548006795384,"score_gpt":0.3263274455219592,"score_spread":0.3139619654540053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}