{"id":"W2955792169","doi":"10.1080/19336950.2019.1638695","title":"pHluorin-tagged TRPV1 shines light on capsaicin tachyphylaxis","year":2019,"lang":"en","type":"letter","venue":"Channels","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Capsaicin; Tachyphylaxis; TRPV1; Chemistry; Transient receptor potential channel; Cell biology; Biology; Pharmacology; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity","insufficient_payload"],"category_scores_codex":[0.0002042031,0.0009410541,0.0009482836,0.0005400162,0.0002963726,0.000222488,0.001228691,0.001434254,0.00103406],"category_scores_gemma":[0.000407984,0.000723586,0.0005146203,0.0005388489,0.0001434755,0.0001926162,0.0002102354,0.002690713,0.006645759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000157146,"about_ca_system_score_gemma":0.00009380763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000300206,"about_ca_topic_score_gemma":0.000001302164,"domain_scores_codex":[0.9952601,0.0002955745,0.000560676,0.001662205,0.001052653,0.00116886],"domain_scores_gemma":[0.9979716,0.0005586432,0.0003967164,0.0008533644,0.00008530189,0.0001343909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002361602,0.00006341226,0.000001612822,0.0001972249,0.00001584947,0.0003386597,0.0004645024,0.00006991152,0.02159427,0.00003780586,0.9767726,0.0004205528],"study_design_scores_gemma":[0.0003493047,0.0002711577,0.000001037451,0.0001828294,0.00001507552,0.00002705048,0.00001717989,0.00007645591,0.3223661,0.0001350868,0.675908,0.0006507338],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.02693441,0.0003124909,0.00003505008,0.8784342,0.06170112,0.001858858,0.0003984749,0.0006665041,0.02965884],"genre_scores_gemma":[0.08458057,0.0002108294,0.000009653919,0.6932036,0.03124007,0.0001178724,0.0001505977,0.0003069099,0.1901799],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.3008646,"threshold_uncertainty_score":0.9998791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04030683450160799,"score_gpt":0.259688859439395,"score_spread":0.219382024937787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}