{"id":"W2955835283","doi":"10.1039/c9dt02078k","title":"Ruthenium–arene complexes bearing naphthyl-substituted 1,3-dioxoindan-2-carboxamides ligands for G-quadruplex DNA recognition","year":2019,"lang":"en","type":"article","venue":"Dalton Transactions","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Horizon 2020; HORIZON EUROPE Marie Sklodowska-Curie Actions; Seventh Framework Programme; Horizon 2020 Framework Programme; European Commission","keywords":"Ruthenium; Bearing (navigation); Chemistry; DNA; Combinatorial chemistry; G-quadruplex; Stereochemistry; Medicinal chemistry; Catalysis; Organic chemistry; Biochemistry; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001074828,0.0002238362,0.0002105438,0.00005730148,0.0001979566,0.00004466723,0.0001859904,0.0002310607,0.0002740505],"category_scores_gemma":[0.00001848468,0.0002385036,0.0002148038,0.0001162084,0.00007290448,0.00001528241,0.00001172169,0.0001341929,0.00004997538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002395055,"about_ca_system_score_gemma":0.00006282232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000229736,"about_ca_topic_score_gemma":0.00003159882,"domain_scores_codex":[0.9988067,0.00001083032,0.0002720146,0.000453559,0.0001284155,0.000328469],"domain_scores_gemma":[0.9992922,0.00002884317,0.00008460257,0.0003691882,0.0001120892,0.000113083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000140308,0.00009186385,0.0001522564,0.00007418374,0.0001100378,6.644053e-7,0.00006165385,0.0001108198,0.9959122,0.00001461889,0.0002439138,0.003087467],"study_design_scores_gemma":[0.001113947,0.00014182,0.0004531203,0.00003830797,0.00006963378,0.00002117908,0.0001598239,0.0002440709,0.9821885,0.0001420168,0.01510315,0.0003244932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821829,0.0001667151,0.01492013,0.0001358595,0.0003785912,0.0003559722,0.0003003285,0.00007066522,0.001488801],"genre_scores_gemma":[0.9959126,0.0001071758,0.00103708,0.0001071763,0.0002229998,0.00009020005,0.001282163,0.00004731803,0.001193358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01485923,"threshold_uncertainty_score":0.9725896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01601878849933373,"score_gpt":0.2417770530544924,"score_spread":0.2257582645551587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}