{"id":"W2955852486","doi":"10.1158/1538-7445.am2019-ct059","title":"Abstract CT059: A Phase Ib open label multicenter study with a HER2/neu peptide vaccine administered with cisplatin and 5-fluorouracil or capecitabine chemotherapy shows safety, immunogenicity and clinical response in patients with HER2/Neu overexpressing advanced cancer of the stomach","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Immunogenicity; Peptide vaccine; Capecitabine; Internal medicine; Cohort; Adjuvant; Phases of clinical research; Tolerability; Chemotherapy; Oncology; Gastroenterology; Cancer; Adverse effect; Immunology; Antibody; Epitope; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001559623,0.001551625,0.001559107,0.0004027383,0.0004423804,0.000814858,0.0007975188,0.001098871,0.001901955],"category_scores_gemma":[0.000658448,0.0005160829,0.001010336,0.0003757585,0.001431353,0.0008919159,0.0003321385,0.002698943,0.0005451602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008645369,"about_ca_system_score_gemma":0.001297725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009021256,"about_ca_topic_score_gemma":0.001296185,"domain_scores_codex":[0.9994492,0.0002566206,0.00003544021,0.00009894078,0.00004761291,0.000112183],"domain_scores_gemma":[0.9993425,0.00007870544,0.000129723,0.00006918968,0.00004467511,0.0003351439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6013587,0.1682448,0.007853794,0.0005165511,0.0008311143,0.0002987646,0.0003861546,0.001983449,0.1776245,0.0001901859,0.001699801,0.03901212],"study_design_scores_gemma":[0.1386931,0.8401144,0.006866114,0.00001573352,0.0002207893,0.000165663,0.00004005506,0.000674977,0.01246235,0.00004411098,0.0006853044,0.0000174319],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982339,0.0003159934,0.0002343424,0.00008244933,0.00004613425,0.0005977832,0.000182823,0.0000311662,0.000275303],"genre_scores_gemma":[0.995393,0.0003995802,0.0008608083,0.0002222686,0.00009899899,0.0008852895,0.001101716,0.00001508712,0.001023316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001901955,"threshold_uncertainty_score":0.00824821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0766206036349271,"score_gpt":0.4608376647990083,"score_spread":0.3842170611640812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}