{"id":"W2955853802","doi":"10.1158/1538-7445.am2019-7","title":"Abstract 7: Discovery of OICR-10268: A potent and selective BCL6 inhibitor","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"BCL6; Lymphoma; Cancer; Cancer research; Germinal center; Medicine; Internal medicine; Immunology; B cell; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001053567,0.0004731347,0.0003739054,0.0002887429,0.0001718576,0.0004308759,0.0004070064,0.0004131085,0.004137409],"category_scores_gemma":[0.000113225,0.0001286007,0.0001983205,0.0002246583,0.0001141537,0.0002308806,0.0002873859,0.0006948053,0.001676115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000258356,"about_ca_system_score_gemma":0.0003253022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006474733,"about_ca_topic_score_gemma":0.001179808,"domain_scores_codex":[0.9999337,0.000005838423,0.000003960974,0.00001044997,0.00002643369,0.00001964825],"domain_scores_gemma":[0.9999613,0.000001927962,0.000004957325,0.000001830637,0.000009995877,0.0000199768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008818282,0.0007348782,0.0006916584,0.0006801395,0.00005594811,0.001062482,0.00006210018,0.001882562,0.889585,0.002447827,0.01284626,0.08906934],"study_design_scores_gemma":[0.001718143,0.007664436,0.003436346,0.0001842603,0.0001589417,0.003463456,0.00007964753,0.007693088,0.84745,0.0007253453,0.1273566,0.0000697294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8724298,0.03498381,0.01831473,0.003813824,0.001401523,0.001172722,0.004544934,0.001210806,0.06212782],"genre_scores_gemma":[0.927145,0.01684038,0.009822208,0.0013444,0.0001388545,0.0001907804,0.004461788,0.00006548841,0.03999096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004137409,"threshold_uncertainty_score":0.01384097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05675449112698437,"score_gpt":0.4118218250370835,"score_spread":0.3550673339100991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}