{"id":"W2955899397","doi":"10.1158/1538-7445.am2019-ct019","title":"Abstract CT019: Population pharmacokinetics of an aurora kinase A inhibitor, LY3295668 erbumine (AK-01), in patients with locally advanced or metastatic solid tumors","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Eli Lilly (Canada); McGill University Health Centre; Jewish General Hospital","funders":"","keywords":"Pharmacokinetics; Medicine; Pharmacology; Population; Cmax; Aurora inhibitor; Pharmacodynamics; NONMEM; Dosing; Aurora A kinase; Kinase; Internal medicine; Oncology; Cancer; Chemistry; Cell cycle; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004910778,0.0002922709,0.0004536172,0.0001786165,0.0001344951,0.0004603721,0.0001526286,0.0002610755,0.0009462874],"category_scores_gemma":[0.001291988,0.0001751367,0.0002127956,0.0002315027,0.0002078871,0.0003453079,0.0001704029,0.0006786485,0.0002954716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004719603,"about_ca_system_score_gemma":0.0003701827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008280744,"about_ca_topic_score_gemma":0.0004513212,"domain_scores_codex":[0.9997841,0.00008401299,0.000011979,0.00005640677,0.00004071896,0.00002269808],"domain_scores_gemma":[0.9995587,0.0001298134,0.000122616,0.00003222861,0.0000345159,0.0001220674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2414038,0.004850933,0.3711715,0.0002712949,0.0008281306,0.001142574,0.0007016138,0.02145646,0.200839,0.0004753013,0.003177817,0.1536817],"study_design_scores_gemma":[0.006833154,0.1800603,0.7200534,0.00003372936,0.0006829226,0.002682137,0.0002618076,0.0278313,0.05353795,0.0003899391,0.007565041,0.00006837023],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998007,0.0003921587,0.0006242815,0.00003151057,0.00000395281,0.00005548084,0.0002858169,0.00005254294,0.0005472568],"genre_scores_gemma":[0.9991152,0.0000714185,0.0002329739,0.00002365534,0.000006677229,0.00003197288,0.0002591868,0.000006200543,0.0002527502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009462874,"threshold_uncertainty_score":0.003424346,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01911124899870521,"score_gpt":0.355948194728296,"score_spread":0.3368369457295908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}