{"id":"W2955927465","doi":"10.1161/circulationaha.118.038814","title":"Use of Genetic Variants Related to Antihypertensive Drugs to Inform on Efficacy and Side Effects","year":2019,"lang":"en","type":"article","venue":"Circulation","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":172,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Global Health Research","funders":"U.S. National Library of Medicine; NIHR Imperial Biomedical Research Centre; Medical Research Council; National Heart, Lung, and Blood Institute; UK Dementia Research Institute; Public Health England; Deutsche Forschungsgemeinschaft; Deutscher Akademischer Austauschdienst; European Commission; Imperial College London; Imperial College Healthcare NHS Trust; National Institute of General Medical Sciences; National Institute for Health and Care Research; Wellcome Trust; Alzheimer's Society; Alexander S. Onassis Public Benefit Foundation; Cancer Research UK","keywords":"Medicine; Mendelian randomization; Internal medicine; Antihypertensive drug; Biobank; Odds ratio; Stroke (engine); Randomized controlled trial; Bioinformatics; Pharmacology; Blood pressure; Genetics; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005049382,0.00037848,0.0004657843,0.001373934,0.0003405897,0.0008906,0.0005410508,0.0006975247,0.003226308],"category_scores_gemma":[0.01569815,0.0001606813,0.0005783356,0.002052751,0.0006066878,0.0004645592,0.0005571563,0.0007489085,0.00028986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005427302,"about_ca_system_score_gemma":0.0005531367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002589217,"about_ca_topic_score_gemma":0.002945583,"domain_scores_codex":[0.9943256,0.003351196,0.0005207312,0.0008844266,0.0007799122,0.000138063],"domain_scores_gemma":[0.9766118,0.01251827,0.007739468,0.001758578,0.0009267331,0.0004452057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007353649,0.00007477916,0.9673231,0.0002243446,0.0008098288,0.0003065346,0.0003341914,0.0004816371,0.001656884,0.0009732214,0.0007304258,0.02634975],"study_design_scores_gemma":[0.0001129026,0.0003270709,0.9868283,0.0002374857,0.0008178437,0.001155546,0.0001769509,0.00171336,0.002011656,0.00314736,0.003444687,0.00002685629],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9662022,0.009038983,0.009527864,0.002809839,0.000114856,0.0001167886,0.00404384,0.00005110811,0.008094579],"genre_scores_gemma":[0.9939159,0.001162117,0.003573452,0.0003806237,0.00006170703,0.00004928589,0.0005927501,0.000006978769,0.0002570565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005049382,"threshold_uncertainty_score":0.02670395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01242625538131355,"score_gpt":0.2505338008541986,"score_spread":0.2381075454728851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}