{"id":"W2955927465","doi":"10.1161/circulationaha.118.038814","title":"Use of Genetic Variants Related to Antihypertensive Drugs to Inform on Efficacy and Side Effects","year":2019,"lang":"en","type":"article","venue":"Circulation","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":172,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Global Health Research","funders":"U.S. National Library of Medicine; NIHR Imperial Biomedical Research Centre; Medical Research Council; National Heart, Lung, and Blood Institute; UK Dementia Research Institute; Public Health England; Deutsche Forschungsgemeinschaft; Deutscher Akademischer Austauschdienst; European Commission; Imperial College London; Imperial College Healthcare NHS Trust; National Institute of General Medical Sciences; National Institute for Health and Care Research; Wellcome Trust; Alzheimer's Society; Alexander S. Onassis Public Benefit Foundation; Cancer Research UK","keywords":"Medicine; Mendelian randomization; Internal medicine; Antihypertensive drug; Biobank; Odds ratio; Stroke (engine); Randomized controlled trial; Bioinformatics; Pharmacology; Blood pressure; Genetics; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000107454,0.00009322739,0.0001637423,0.0000694308,0.00003493807,0.000008231558,0.00004684032,0.0001370248,0.000003368904],"category_scores_gemma":[0.0005062096,0.00009103305,0.0000317035,0.0001308783,0.00001233287,0.00000327686,0.00004639537,0.00003713316,0.00005991126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001363163,"about_ca_system_score_gemma":0.0000202557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002327474,"about_ca_topic_score_gemma":0.000002373248,"domain_scores_codex":[0.9992765,0.00005279066,0.0002135156,0.0002381511,0.00007445525,0.0001446375],"domain_scores_gemma":[0.9994103,0.00008368842,0.00008323374,0.0002436273,0.0001057372,0.00007337191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0000851812,0.00004372275,0.259538,0.00002646336,0.00008287183,8.934888e-7,0.0003666237,0.02941448,0.6909513,0.0001962387,0.0003089382,0.0189852],"study_design_scores_gemma":[0.0004320829,0.0002772059,0.9936052,0.0000223095,0.00001635235,0.000003196383,0.00001592228,0.0007797001,0.003929755,0.00005928593,0.0007512309,0.0001077427],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998133,0.00003649459,0.0005711531,0.0002202537,0.000131725,0.0004873775,0.000004643056,0.000006050446,0.0004093007],"genre_scores_gemma":[0.997691,0.00001302573,0.001297157,0.00080198,0.00002111894,0.000007800109,0.00004125389,0.00001180287,0.0001148866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7340672,"threshold_uncertainty_score":0.371222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01242625538131355,"score_gpt":0.2505338008541986,"score_spread":0.2381075454728851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}