{"id":"W2955937053","doi":"10.1158/1538-7445.am2019-1424","title":"Abstract 1424: Preclinical development of TAC01-CD19, a CD19 specific T-cell Antigen Coupler (TAC) therapy for the treatment of CD19-positive B cell malignancies","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"CD19; Chimeric antigen receptor; T cell; Cancer research; Antigen; Medicine; Immunology; B cell; Antibody; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000413321,0.0005876987,0.0003943054,0.0003747508,0.0001941411,0.0003918148,0.0004527906,0.0005553389,0.003966036],"category_scores_gemma":[0.0001739087,0.000175491,0.0003409531,0.0001963286,0.0002068053,0.0003234282,0.0001365502,0.001169884,0.001126799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003102187,"about_ca_system_score_gemma":0.0006209731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005736738,"about_ca_topic_score_gemma":0.000675144,"domain_scores_codex":[0.9998596,0.00003093426,0.00001156883,0.0000227059,0.00003914849,0.00003614368],"domain_scores_gemma":[0.9998666,0.00001639651,0.0000258877,0.00001629201,0.00002299118,0.0000517612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004081878,0.006815859,0.0005602399,0.0002706908,0.00006720416,0.0001625672,0.0000694089,0.0008435213,0.9640537,0.0003493153,0.001678287,0.02104735],"study_design_scores_gemma":[0.002890862,0.09190958,0.00423989,0.00004188593,0.0002256634,0.000771146,0.00003506814,0.001662752,0.8824459,0.000149179,0.01561339,0.00001474273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827727,0.00310994,0.00457186,0.0002820368,0.0001714723,0.001120919,0.0018961,0.0002621507,0.005812789],"genre_scores_gemma":[0.977833,0.002735685,0.003735062,0.000196225,0.00007918067,0.001032954,0.004722143,0.00005789999,0.009607982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003966036,"threshold_uncertainty_score":0.0132677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1730607265114423,"score_gpt":0.4446102306505628,"score_spread":0.2715495041391205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}