{"id":"W2955946374","doi":"10.1016/j.molmet.2019.06.021","title":"GDF10 blocks hepatic PPARγ activation to protect against diet-induced liver injury","year":2019,"lang":"en","type":"article","venue":"Molecular Metabolism","topic":"GDF15 and Related Biomarkers","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; McMaster University","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Steatosis; Endocrinology; Internal medicine; Endoplasmic reticulum; Lipid metabolism; Adipose tissue; Biology; Lipid droplet; Transforming growth factor; Liver injury; Triglyceride; Fatty liver; Cell biology; Cholesterol; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002291782,0.0002590427,0.000412901,0.0002660278,0.00006078861,0.00002683875,0.0001334601,0.0002198542,0.0001423831],"category_scores_gemma":[0.0001422129,0.0002094253,0.0001915064,0.0005190358,0.00002239801,0.00007298875,0.00007986533,0.0003619507,0.0004503076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005846013,"about_ca_system_score_gemma":0.00009610809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008751401,"about_ca_topic_score_gemma":0.000001155176,"domain_scores_codex":[0.9983356,0.00009840859,0.0002868383,0.0004380034,0.0004599982,0.0003811623],"domain_scores_gemma":[0.9989604,0.00001681043,0.00009301386,0.0005548684,0.0001294181,0.0002455151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004538323,0.000107376,0.0003602307,0.00006149003,0.000205788,0.00006168248,0.0002270815,0.000009681792,0.9848387,0.00004909295,0.0004185187,0.01320652],"study_design_scores_gemma":[0.002178682,0.000506021,0.03228846,0.0002863468,0.0003076811,0.00001599869,0.00006683453,0.000592907,0.9198738,0.00005725744,0.04334716,0.0004788424],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991254,0.0003755632,0.0002803977,0.001051999,0.0004861082,0.001903992,0.000003256042,0.0001150279,0.00452966],"genre_scores_gemma":[0.9946986,0.00003746061,0.0008198562,0.00299979,0.0001052051,0.00007973152,0.00002802233,0.00005515547,0.001176223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06496489,"threshold_uncertainty_score":0.8540117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006910392692507674,"score_gpt":0.2364648215534449,"score_spread":0.2295544288609372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}