{"id":"W2955948108","doi":"10.1002/ijc.32555","title":"Circulating markers of cellular immune activation in prediagnostic blood sample and lung cancer risk in the Lung Cancer Cohort Consortium (LC3)","year":2019,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Cancer Institute; National Heart, Lung, and Blood Institute; Faculty of Medicine and Health, University of Sydney; Norges Forskningsråd; National Health and Medical Research Council; Medical Research Council; National Institute on Drug Abuse; York University; Cancer Council Victoria; Norges Teknisk-Naturvitenskapelige Universitet; New York City Department of Health and Mental Hygiene; World Health Organization; Centre International de Recherche sur le Cancer; Women's Health Initiative; Norwegian Institute of Public Health; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Lung cancer; Medicine; Neopterin; Internal medicine; Oncology; Kynurenine; Cancer; Prospective cohort study; Odds ratio; Cohort; Cohort study; Gastroenterology; Immunology; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004239606,0.0001161605,0.0002134848,0.0002198238,0.00002886558,0.00004316062,0.0003572522,0.00005069276,0.0003288658],"category_scores_gemma":[0.0007141033,0.000092263,0.00006931226,0.0002233258,0.00007633884,0.0003067113,0.00004265893,0.0003188526,2.437233e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001786776,"about_ca_system_score_gemma":0.0002207829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004161251,"about_ca_topic_score_gemma":0.0004949886,"domain_scores_codex":[0.9983627,0.0001565546,0.0005379856,0.000185179,0.0005912999,0.000166235],"domain_scores_gemma":[0.9980417,0.001014724,0.0006681566,0.0000973276,0.0001477323,0.00003033535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002005415,0.00007390977,0.8526108,0.00003825053,0.0001112241,0.00001585198,0.0007599059,0.00771966,0.1367085,0.0001097896,0.00008084021,0.001570715],"study_design_scores_gemma":[0.002556593,0.00004201902,0.9337171,0.0007546936,0.00007537076,0.00001307763,0.000276699,0.008988269,0.05307787,0.0002582602,0.00009638593,0.0001436913],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943199,0.003463689,0.0001814472,0.0007360028,0.0007790148,0.0003143814,0.00006042925,0.000003483315,0.0001416448],"genre_scores_gemma":[0.9966826,0.002790967,0.00002701664,0.0002984468,0.0001302274,0.0000378128,0.000001491464,0.00001240133,0.00001901186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08363064,"threshold_uncertainty_score":0.6290594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008661705142776857,"score_gpt":0.2846055497957305,"score_spread":0.2759438446529536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}