{"id":"W2955959842","doi":"10.1158/1538-7445.am2019-ct166","title":"Abstract CT166: A Phase I/II, open-label, two part study of GSK3359609 in combination with tremelimumab in participants with selected, advanced solid tumors","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Princess Margaret Cancer Centre","funders":"","keywords":"Tremelimumab; Medicine; Internal medicine; Oncology; Cancer; Ipilimumab; Immunotherapy; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002502157,0.002976902,0.002733574,0.0006767561,0.000880506,0.0009565686,0.001279308,0.002275531,0.00977142],"category_scores_gemma":[0.001192053,0.0009991656,0.001668997,0.0005234498,0.001246548,0.001487321,0.0005360566,0.003798113,0.002751347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001000789,"about_ca_system_score_gemma":0.00238826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001010584,"about_ca_topic_score_gemma":0.002523753,"domain_scores_codex":[0.9992847,0.0003410933,0.00005087799,0.0001204563,0.00008457782,0.0001183586],"domain_scores_gemma":[0.998759,0.0001355381,0.0002416871,0.00007984647,0.0001036189,0.0006802852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.772626,0.151193,0.003655795,0.001200268,0.0007193198,0.0003116977,0.0002336885,0.0007779629,0.03545568,0.0001449369,0.003001289,0.03068038],"study_design_scores_gemma":[0.4035598,0.5893109,0.004036297,0.00001846091,0.0001959051,0.000138184,0.00003976081,0.0002180458,0.001337385,0.00007198276,0.00105441,0.00001877849],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816383,0.001313454,0.0008745916,0.0005976578,0.0002271106,0.01098647,0.002446445,0.0001908598,0.001725047],"genre_scores_gemma":[0.9624436,0.002048849,0.003667429,0.002080628,0.0005674665,0.01589042,0.00403283,0.00006791127,0.009200838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00977142,"threshold_uncertainty_score":0.03268862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1232677421746893,"score_gpt":0.4734657322207632,"score_spread":0.3501979900460739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}